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Table 3 Summary of the Growth Hormone Treatment in 8 Chinese FHS patients

From: Novel genotypes and phenotypes among Chinese patients with Floating-Harbor syndrome

  Patient 3 Patient 6 Patient 7 Patient 8 Patient 9 Patient 10 Patient 11 Patient 12
Gender Male Female Male Female Male Male Female Female
SRCAP Mutation c.7330C > T
/p.Arg2444Ter
c.7330C > T
/p.Arg2444Ter
c.7245_7246delAT/p.Ser2416ArgfsTer26 c.7330C > T
/p.Arg2444Ter
c.7330C > T
/p.Arg2444Ter
c.7303C > T
/p.Arg2435Ter
c.7303C > T
/p.Arg2435Ter
c.7466C > G
/p.Ser2489Ter
GHD Yes No ND No No No No No
Initial age of treatment 5Y2M 2Y 4Y10M 5Y 6Y6M 5Y2M 1Y5M 2Y3 M
Height at the initiation of treatment (SDS) 92.5 cm (−4.52) 74.7 cm (−3.62) 92.3 cm (−4.12) 93.8 cm (−3.84) 95 cm (−5.30) 92.7 cm(−4.47) 68.5 cm (−4.17) 75.0 cm (− 4.17)
HV before treatment (cm/year) 4.5 NA NA ~ 3.1 ~ 3 4.5 NA NA
Dosage & Usage 0.15 IU/kg.p.d (short-acting) 1.2 IU/kg.p.d (short-acting) 1.18 ~ 1.4 IU/kg.p.w (long-acting) 0.17 mg/kg.p.w (long-acting) 0.2 IU/kg.p.d (short-acting) 0.14~0.17 IU/kg.p.d (short-acting) 0.13~0.2 IU/kg.p.d (short-acting) 0.125 IU/kg.p.d (short-acting)
Duration of treatment 1Y 1 M 4Y + 2 M 1Y + 7 M 4Y + 3 M 4Y + 3 M 2Y + 2 M 3 M
Height at one year treatment(SDS) 98 cm (−4.40) na 99.5 cm (−3.76) 100.5 cm (− 3.50) 101.9 cm (− 4.78) 98 cm (− 4.40) 87 cm (−2.77)a na
Height at last examination(SDS) 98 cm (− 4.40) na 120.5 cm (−2.56) 103.4 cm (− 3.49) 119 cm (− 3.86) 118 cm (− 3.31) 88.6 cm (− 2.96) 77.9 cm (− 3.81)
First-year delta height SDS 0.12 na 0.36 0.34 0.52 0.07 > 0.7 na
Total height SDS 0.12 na 1.56 0.35 1.44 1.16 1.21 na
Annualized height SDS 0.12 na 0.37 0.22 0.34 0.27 0.56 na
HV during the first year of treatment (cm/year) 5.5 na 6.64 6.7 6.9 5.3 10.1 na
HV increase during the first-year (cm/year) 1 na na ~ 3.6 ~ 3.9 0.8 na na
GH Treatment response Poor ND Good Modest Good Poor Good ND
  1. ND undetermined, na not applicable, NA data not available, a: data collected at one year and ten months after GH treatment