Table 1 Standardised Uveitis Nomenclature (SUN) Disease activity grading schemes and Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIGWUC) outcome parameters [11, 12]
SUN Grades (2005) | |
 Anterior chamber cells | Non-linear ordinal scale: 0 (no cells in examined field), 0.5+ (1–5 cells), 1+ (6–15), 2+ (16–25), 3+ (26–50), 4+ (> 50 cells in examined field) |
 Anterior chamber flare | Non-linear ordinal scale from 0 (no clouding of view of anterior structures) to 4+ (intense fibrin deposition in anterior chamber) |
 Vitreous haze | Non-linear ordinal scale from 0 (no clouding of view through vitreous) to 4 (unable to see through vitreous gel) |
MIGWUC outcome domains (2012) | |
 Grade of activity in anterior chamber | Slit lamp exam (subjective measure of cells and flare) and laser photometry (objective measure of flare), and number of visits with active uveitis |
 Visual acuity | Appropriate for age at testing |
 Development of structural complications | Slit lamp examination for anterior structural complications Presence of high eye pressure or glaucoma (diagnostic protocol not clear) Slit lamp examination or imaging for posterior structural complications |
 Quality of life | Child Health Assessment Questionnaire a ; Child Health Questionnaire a Pediatric Quality of life Inventory; Uveitis-specific quality of life instrumentb |
 Overall uveitis related disability | Visual analog scale scoring undertaken by child, family, ophthalmologist or rheumatologist |
 Social outcome | School absence |
 Anti-inflammatory medication | Reduction in corticosteroid use |
 Surgery | Yes / no |
 Biomarkers | Research tools |