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Table 1 Standardised Uveitis Nomenclature (SUN) Disease activity grading schemes and Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIGWUC) outcome parameters [11, 12]

From: Under-utilisation of reproducible, child appropriate or patient reported outcome measures in childhood uveitis interventional research

SUN Grades (2005)
 Anterior chamber cells Non-linear ordinal scale: 0 (no cells in examined field), 0.5+ (1–5 cells), 1+ (6–15), 2+ (16–25), 3+ (26–50), 4+ (> 50 cells in examined field)
 Anterior chamber flare Non-linear ordinal scale from 0 (no clouding of view of anterior structures) to 4+ (intense fibrin deposition in anterior chamber)
 Vitreous haze Non-linear ordinal scale from 0 (no clouding of view through vitreous) to 4 (unable to see through vitreous gel)
MIGWUC outcome domains (2012)
 Grade of activity in anterior chamber Slit lamp exam (subjective measure of cells and flare) and laser photometry (objective measure of flare), and number of visits with active uveitis
 Visual acuity Appropriate for age at testing
 Development of structural complications Slit lamp examination for anterior structural complications
Presence of high eye pressure or glaucoma (diagnostic protocol not clear)
Slit lamp examination or imaging for posterior structural complications
 Quality of life Child Health Assessment Questionnaire a ; Child Health Questionnaire a
Pediatric Quality of life Inventory; Uveitis-specific quality of life instrumentb
 Overall uveitis related disability Visual analog scale scoring undertaken by child, family, ophthalmologist or rheumatologist
 Social outcome School absence
 Anti-inflammatory medication Reduction in corticosteroid use
 Surgery Yes / no
 Biomarkers Research tools
  1. aCHAQ and CHQ are functional assessments rather than quality of life metrics
  2. bAs yet, there is no validated instrument