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Table 2 The immunohistochemical and molecular genetic analysis of 14 cases

From: Ovarian primary primitive neuroectodermal tumor: a review of cases at PUMCH and in the published literature

Case IHC Karyotype, t (11,22) Molecular genetic analysis
Kanbour-Shakir, 1993 (Kanbour-Shakir et al. 1993) [11] NSE(+), EMA(+) N/A N/A
Lawlor, 1997 (Lawlor et al. 1997) [12] CD99(−), NSE(+) EWS/FLI1, EWS/ERG gene fusions (−); MYCN gene amplification (−)
Kawauchi,1998 (Kawauchi et al. 1998) [13] CD99(+) + EWS/FLI1(+);
PUMCH Case 1, 2003a CD99(−) N/A N/A
Chow, 2004 (Chow et al. 2004) [15] CD99(+), NSE(+) N/A N-myc, EGFR, FASL, GITRL overexpression, ARHI, FAT low expression
Kim, 2004 (Kim et al. 2004) [16] CD99(+), FLI-1(+) N/A N/A
PUMCH Case 2, 2005a CD99(+), NSE(+) N/A N/A
Fischer, 2006 (Fischer et al. 2006) [17] CD99(+), NSE(+), FlI-1(+) N/A N/A
Ateser, 2007 (Ateser et al. 2007) [18] CD99(+) N/A N/A
Anfinan, 2009 (Anfinan et al. 2008) [19] CD99(+), NSE(+) N/A N/A
Ostwal,2012 (Ostwal et al. 2012) [20] CD99(+), FLI-1(+) + EWS/FLI1(+); EWS/WT1(−)
Chu, 2014 (Chu et al. 2014) [21] CD99(−) N/A N/A
PUMCH Case 3, 2014a CD99(−), NSE(+) N/A N/A
PUMCH Case 4, 2016a CD99(+) N/A N/A
  1. Abbreviations: CD99 Cluster of differentiation 99, EGFR Epidermal growth factor receptor, EMA Epithelial membrane antigen, FLI-1 Friend leukemia integration 1 transcription factor, GITRL Glucocorticoid-induced tumor necrosis factor receptor ligand, IHC Immunohistochemistry, N/A Not available, N-myc N-myc proto-oncogene protein, NSE Neuron-specific enolase
  2. aThese cases are reported in this study