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Table 3 6-MWT and FVC in Malaysian MPS IVA patients by age group compared with other studies

From: Clinical, biochemical and genetic profiles of patients with mucopolysaccharidosis type IVA (Morquio A syndrome) in Malaysia: the first national natural history cohort study

 

Mean ± SD

This study

Harmatz et al. [15]

Lin et al. [16]

6-MWT

 0–4 years old

246.9 m

(n = 1)

251.6 ± 121.5 m

(n = 37)

–

 5–11 years old

218.8 ± 98.2 m

(n = 4)

232.5 ± 140.1 m

(n = 127)

–

 12–18 years old

123.7 ± 116.4 m

(n = 5)

181.2 ± 177.3 m

(n = 84)

–

 > 18 years old

119.3 ± 121.2 m

(n = 3)

193.1 ± 148.5 m

(n = 68)

–

 Overall 6-MWTa

161.4 ± 110.1 m

(n = 13)

212.6 ± 152.2 m

(n = 316)

235.3 ± 125.5 m

(n = 11)

 Overall age

15.5 ± 8.1 years

14.5 years

12.6 ± 6.6 years

Spirometry, FVC

 ≤ 18 years old

0.6 ± 0.1 L

(n = 5)

1.1 ± 0.7 L

(n = 256)

–

 > 18 years old

0.9 ± 0.2 L

(n = 3)

1.5 ± 1.1 L

(n = 69)

–

  1. Abbreviations: 6-MWT 6-min walk test, FVC Forced vital capacity, SD Standard deviation
  2. a Only patients who completed the test were included