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Table 1 Potential mimics of fibrous dysplasia by skeletal site

From: Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS international consortium

SiteDifferential diagnosis
GeneralCancer (primary or secondary) or hematologic malignancy including solitary plasmocytoma sarcoma
Simple bone cyst (unicameral)
Giant cell tumours
Aneurysmal bone cyst
Paget’s disease of bone
Neurofibromatosis type I
Cutaneous Skeletal Hypophosphatemia syndrome
Langerhans cell Histiocytosis
Osteitis Fibrosa Cystica (Recklinghausen)
Craniofacial bonesOssifying fibroma
 Fibro-osseous lesion
Aseptic mandibular osteitis (SAPHO syndrome)
Central giant-cell granuloma
TibiaAdamantinoma and osteofibrous dysplasia