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Table 2 Main clinical manifestations in 92 infants with congenital tuberculosis

From: Diagnosis and treatment of congenital tuberculosis: a systematic review of 92 cases

 

Age at onset

 

Clinical manifestations

≤14 days n/N (%)

> 14 days n/N (%)

Total

χ 2

P-value

Systemic manifestations

 Fever

31/41 (75.61)

43/51 (84.31)

74/92 (80.43)

1.094

0.296

 Cyanosis

17/41 (41.46)

22/51 (43.14)

39/92 (42.39)

0.026

0.872

 Jaundice

13/41 (31.71)

7/51 (13.73)

20/92 (21.74)

4.320

0.038

 Pallor

7/41 (17.07)

10/51 (19.61)

17/92 (18.48)

0.097

0.756

 Lymphadenopathy

4/41 (9.76)

4/51 (7.84)

8/92 (8.70)

0.000

1.0001

Respiratory system

 Respiratory distress

26/41 (63.41)

29/51 (56.86)

55/92 (59.78)

0.406

0.524

 Cough

17/41 (41.46)

33/51 (64.71)

50/92 (54.35)

4.949

0.026

 Pulmonary moist rales

12/41 (29.27)

20/51 (39.22)

32/92 (34.78)

0.991

0.319

 Triple restriction

5/41 (12.20)

10/51 (19.61)

15/92 (16.30)

0.915

0.339

 Foaming at the mouth

3/41 (7.32)

2/51 (3.92)

5/92 (5.43)

0.063

0.8011

Digestive system

 Hepatomegaly

28/41 (68.29)

35/51 (68.63)

63/92 (68.48)

0.001

0.973

 Splenomegaly

18/41 (43.90)

26/51 (50.98)

44/92 (47.83)

0.456

0.499

 Abdominal distention

10/41 (24.39)

11/51 (21.57)

21/92 (22.83)

0.103

0.749

 Poor appetite

2/41 (4.88)

8/51 (15.69)

10/92 (10.87)

1.738

0.1871

 Poor feeding

4/41 (9.76)

5/51 (9.80)

9/92 (9.78)

0.000

1.0001

 Vomiting

2/41 (4.88)

4/51 (7.84)

6/92 (6.52)

0.022

0.8831

 Diarrhea

2/41 (4.88)

4/51 (7.84)

6/92 (6.52)

0.022

0.8831

Nervous system

 Mental fatigue

6/41 (14.63)

11/51 (21.57)

17/92 (18.48)

0.726

0.394

 Seizures

5/41 (12.20)

5/51 (9.80)

10/92 (10.87)

0.001

0.9771

Skin

7/41 (17.07)

3/51 (5.88)

10/92 (10.87)

1.896

0.1681

  1. 1Continuity correction