From: Recommendations for the management of MPS VI: systematic evidence- and consensus-based guidance
Statement | Percentage consensus |
---|---|
With consideration of the associated risks of morbidity and mortality associated with this procedure, HSCT may be an option for patients with MPS VI who have a matched related donor (or unrelated donor), or cord blood grafta Evidence Grade: C (consistent with level 4 studies and extrapolations from level 3 studies) | 86% |
Due to the risk of mortality, it is critical that HSCT is only performed in an institution with a multidisciplinary team experienced in the care of patients with MPS VI Evidence Grade: D (level 3/4 studies with inconsistent risk/benefit results) | 91% |