Table 5 Summary of previous reports on mTOR inhibitor dosing in neonates
mTOR inhibitor | AAO of mTOR inhibitor | Dosing regimen | Dose [mg/m2/d] | Trough levels [ng/ml] | Duration | AE | Prophylaxis | Reference |
|---|---|---|---|---|---|---|---|---|
EVE | NA | 0.25 mg twice per day 2 days per week | NA | 5–15 | 2.5 months | Increase of TG Self-limiting diarrhea Decreased CD/CD8 ratio lymphopenia | TMP/SMX | (Demir et al. 2012) |
Sirolimus | 10 days | 0.4 mg daily | NA | NA | 24 days | Increase of TG | TMP/SMX | (Breathnach et al. 2014) |
EVE | 20 days | 0.1 mg daily | 0.64 | 11 | 34 days | Transient hypokalemia | NA | (Mohamed et al. 2014) |
EVE | 2 days | 0.25 mg twice per day 2 days per week | NA | 3.6–7.8 | 3 months | NA | NA | (Dogan et al. 2015) |
EVE | 4 days | 0.1 mg daily | 0.64 | 11.5 | 42 days | NA | NA | (Goyer et al. 2015) |
EVE | 9 days | 0.1 mg daily | 0.64 | 10.2 | NA | NA | NA | |
EVE | 21 days | NA | 3 | 4–5 | NA | Hyponatremia | antibiotic prophylaxis | (Mlczoch et al. 2015) |
EVE | NA | 0.25 mg twice per day 2 days per week | NA | NA | 4 weeks | NA | NA | (Oztunc et al. 2015) |
EVE | 2 days | 0.15–0.2 mg daily | 1 | 10–15 | 19 days | Toxic levels of 108 ng/ml under initial dose of 0.4–0.45 mg (=1.5-2 mg/m2) | NA | (Wagner et al. 2015) |
EVE | 7 days | 0.25 mg daily | 1 | NA | 10 weeks | Mild mucositis Increase of TG | NA | (Colaneri et al. 2016) |
EVE | NA | 0.25 mg twice per day 2 days per week | NA | 5–10 | NA | NA | NA | (Emir et al. 2017) |
EVE | NA | 0.5 mg daily | NA | NA | NA | NA | NA | (Hoshal et al. 2016) |
EVE | 20 days | 0.1 mg daily | NA | 13.7 | 34 days | Suspected infection | NA | (Aw et al. 2017) |
EVE | 4 days | NA | NA | 11 | 42 days | None | NA | |
EVE | 9 days | 0.1 mg daily | NA | 10.2 | NA | Oral ulcers | NA | |
EVE | 1 day | 0.1 mg daily | NA | 10.2 | 36 days | None | NA | |
EVE | NA | 0.03125 mg daily | 0.12 | 3–7 | 2 weeks | Adenovirus pneumonia High trough levels of 20 ng/ml under 0.125 mg (0.0558 mg/m2) | NA | (Chang et al. 2017) |
EVE | NA | NA | 0.35 | 1.81 | NA | NA | NA | |
EVE | NA | 0.125 mg daily | 0.51 | NA | Na | NA | NA |