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Table 1 Base case and sensitivity analysis by geographic area (SA includes only studies with birth prevalence measure) (detection rate per 100,000 newborns)

From: Systematic literature review and meta-analysis on the epidemiology of methylmalonic acidemia (MMA) with a focus on MMA caused by methylmalonyl-CoA mutase (mut) deficiency

Base case Sensitivity analysis (birth prevalence)
  MMA Isolated MMA MMA Isolated MMA
Region point estimate
(95% CI)
Number of studies I2 point estimate (95% CI) Number of studies I2 point estimate
(95% CI)
Number of studies I2 point estimate
(95% CI)
Number of studies I2
North America 1.22
(0.61–2.01)
10 79.79% 0.38
(0.09–0.79)
8 53.23% 1.36
(0.71–2.20)
9 76.46% 0.42
(0.09–0.91)
7 53.07%
Europe 1.12
(0.50–1.91)
11 79.22% 0.60
(0.16–1.23)
6 2.17% 1.55
(0.51–3.02)
9 79.95% 0.60
(0.16–1.23)
6 2.17%
Asia-Pacific 0.79
(0.44–1.21)
12
(15 cohorts)
45.46% 0.51
(0.32–0.74)
9
(12 cohorts)
0.00% 1.00
(0.46–1.69)
11 44.76% 0.57
(0.27–0.96)
8 0.00%
MENA 6.04
(4.02–8.41)
6 15.78% 5.69
(2.54–9.87)
2 NA 5.60
(2.94–8.94)
5 21.45% NA NA NA