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Table 4 Median age at first reported occurrence of manifestations/events considered to contribute to HPP clinical burden

From: Frequency and age at occurrence of clinical manifestations of disease in patients with hypophosphatasia: a systematic literature review

Manifestation/event Median age, years (range)
Respiratory symptoms 0.3 (0–1)
Cranial abnormalities 1 (0–12)
Premature loss of teeth 10 (0.5–60)
One or more fractures 43 (0–75)
Multiple fracturesa 33 (0–75)
Pain 44 (0–64)
Gross motor/ambulation difficulties 62 (0.2–90)
Surgery 70 (0.1–83)
  1. HPP-related manifestations/events considered to contribute to the clinical burden of HPP were identified by four clinical experts who had experience in treating patients with HPP. The data shown are the median age at first reported occurrence of such manifestations/events across all ages of first HPP manifestation. Only patients who had been followed longitudinally for at least 1 year were included in this analysis
  2. aMultiple fractures defined as three or more
  3. HPP, hypophosphatasia