Overall n (%) n = 265 | In utero n (%) n = 30 | Infancy n (%) n = 102 | Childhood n (%) n = 78 | Adolescence n (%) n = 9 | Adulthood n (%) n = 46 | |
---|---|---|---|---|---|---|
Patients with at least one manifestation/event | 248 (94) | 25 (83) | 96 (94) | 78 (100) | 9 (100) | 40 (87) |
Manifestation/event | ||||||
Premature loss of teeth | 142 (53.5) | 3 (10.0) | 63 (61.8) | 58 (74.4) | 3 (33.3) | 14 (30.4) |
One or more fractures | 95 (35.8) | 12 (40.0) | 19 (18.8) | 27 (34.6) | 3 (33.3) | 34 (73.9) |
Multiple fracturesa | 60 (22.6) | 2 (6.7) | 13 (12.7) | 19 (24.4) | 2 (22.2) | 24 (52.2) |
Pain | 89 (33.6) | 1 (3.3) | 25 (24.5) | 32 (41.0) | 6 (66.7) | 25 (54.3) |
Gross motor/ambulation difficulties | 82 (30.9) | 7 (23.3) | 41 (40.2) | 18 (23.1) | 1 (11.0) | 15 (32.6) |
Cranial abnormalities | 66 (24.9) | 12 (40.0) | 44 (43.1) | 10 (12.8) | 0 (0.0) | 0 (0.0) |
Surgery | 64 (24.2) | 4 (13.3) | 30 (29.4) | 8 (10.1) | 3 (33.3) | 17 (37.0) |
Dental otherb | 37 (14.0) | 0 (0.0) | 23 (22.5) | 11 (14.1) | 0 (0.0) | 3 (6.5) |
Hospitalizationsc | 33 (12.5) | 1 (3.3) | 18 (17.6) | 6 (7.7) | 2 (22.2) | 6 (13.0) |
Respiratory symptomsc | 19 (7.2) | 5 (16.7) | 14 (13.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Nephrocalcinosis | 11 (4.2) | 2 (6.7) | 8 (7.8) | 1 (1.3) | 0 (0.0) | 0 (0.0) |
Seizures | 7 (2.6) | 3 (10.0) | 3 (2.9) | 0 (0.0) | 0 (0.0) | 1 (2.2) |
Renal insufficiency | 4 (1.5) | 0 (0.0) | 1 (1.0) | 3 (3.8) | 0 (0.0) | 0 (0.0) |
Psychological | 3 (1.1) | 0 (0.0) | 0 (0.0) | 1 (1.3) | 0 (0.0) | 2 (4.3) |