Fig. 3

Kaplan–Meier curves for time to (a) cranial abnormalities and (b) respiratory symptoms in patients with these manifestations or events. Solid lines show the Kaplan–Meier estimation; grey shading denotes probability of being event-free between upper and lower 95% CI. Owing to the distribution of the data, only patients who had been followed longitudinally for at least 1 year and had experienced cranial abnormalities and/or respiratory systems before the age of 5 years were included in this analysis. The x axes in panels a and b are restricted to 5 years and 1 year, respectively. Patients were censored at first occurrence of the clinical symptom of interest, death, or loss to follow-up. CI, confidence interval