Fig. 1

Timing of HPP-related clinical manifestations/events in patients showing first manifestations in (a) infancy, (b) early childhood, and (c) childhood. a Infancy; 0 to < 0.5 years (n = 47). b Early childhood; 0.5 to < 2 years (n = 54). c Childhood; 2 to < 10 years (n = 78). These graphs are examples for patients with HPP in infancy, early childhood, and childhood – see Additional file 4 for additional age groups. Cases are ordered by available follow-up. Only patients who had been followed longitudinally for at least 1 year and who experienced one or more HPP-related manifestations or events of interest were included in this analysis. ‘Resolution of symptoms’ was reported by the author of the case report. ‘Not reported’ defined as either nothing reported for the time period or no manifestations of interest. Anchor visit defined as the first point of contact with the author of the case report. HPP, hypophosphatasia; LTF, lost to follow-up