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Table 2 Variable comparison for TSC LAM versus Sporadic LAM diagnosis

From: Serum endostatin levels are associated with diffusion capacity and with tuberous sclerosis- associated lymphangioleiomyomatosis

Variable

TSC

N = 16

Sporadic

N = 44

Control

N = 25

P

Age (years) (mean ± SE)

41.6 ± 2.9

49.4 ± 1.8

39.4 ± 3.2

0.0031

FEV1 (%) (mean ± SE)5

90.9 ± 4.3

86.7 ± 3.6

0.462

FVC (%) (mean ± SE)5

99.6 ± 3.7

98.1 ± 3.0

0.752

DLCO (%) (mean ± SE)6

65.9 ± 5.9

67.7 ± 2.9

0.683

Endostatin (ng/mL) (mean ± SE)

54.2 ± 6.1

28.9 ± 2.1

30.1 ± 4.0

0.00071

AML

 No, n (%)

0 (0)

25 (56.8)

0.000054

 Yes, n (%)

16 (100)

19 (43.2)

Isolated Reduction in DLCO (< 60%) 6

 No, n (%)

11 (68.8)

39 (95.1)

0.0154

 Yes, n (%)

5 (31.2)

2 (4.9)

  1. 1 Kruskal-Wallis H test
  2. 2 Two-sample T test with unequal variance
  3. 3 Mann-Whitney U test
  4. 4 Fisher’s Exact Test
  5. 542 Sporadic LAM patients in analysis
  6. 641 Sporadic LAM patients in analysis