The natural history of classic galactosemia: lessons from the GalNet registry

Table 4 Gonadal complications

	n	Valid n	%
Female
Puberty		134
Spontaneous puberty	69		51.5
Induced puberty	65		48.5
Primary ovarian insufficiency^a	118	148	79.7
Hormone replacement therapy	86	103	83.5
Tried to conceive	16	95	16.8
Successful pregnancy^b	4	16	25.0
Male
Delayed Puberty^c	3	63	4.8
Cryptorchidism	3	54	5.6
Fathered children	5	64	7.8

^aDiagnosed in women below the age of 40 years, with at least 40 months of amenorrhea and 2 independent, more than 1-month apart, FSH levels in the menopausal state
^bOf women who tried to conceive
^cA delayed puberty was defined as a lack of increase in testicle size by age 14

ISSN: 1750-1172