The natural history of classic galactosemia: lessons from the GalNet registry

Table 3 Neurological, cognitive and mental (psychiatric) complications

	n	Valid n	%
Developmental delay infancy/childhood	167	320	52.2
Motor	18		10.8
Cognitive	66		39.5
Motor and cognitive	83		49.7
Language delay^b	128	164	78.0
Isolated language delay	37	170	21.8
Language and speech disorders^a	192	289	66.4
Speech defect	129	315	41.0
Impairment in vocabulary	117	288	40.6
Impairment in grammar	98	253	38.7
Verbal dyspraxia	67	285	23.5
Dysarthria	49	246	19.9
Neurological complications^a	168	323	52.0
Tremor	104	336	31.0
General motor abnormality	86	319	27.0
Ataxia	40	329	12.2
Seizures	26	320	8.1
Dystonia	24	318	7.5
Mental (psychiatric) and behavioral problems^a	128	288	44.4
Anxiety disorder	67	300	22.3
Depression	38	303	12.5
ADHD	21	286	7.3
Autism spectrum disorder	17	281	6.0

^aDefined as having at least one of the complications in that category, compared to having none of them
^bLanguage delay and motor and/or cognitive developmental delay

ISSN: 1750-1172