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Table 5 Dose-dependent treatment effects in acquired angioedema C1-inhibitor patients without (N = 6) and with (N = 8) anti-C1-INH autoantibodies

From: Angioedema due to acquired C1-inhibitor deficiency: spectrum and treatment with C1-inhibitor concentrate

 

Patients without autoantibodies against C1-INH

(N = 6)

Patients with autoantibodies against C1-INH

(N = 8)

pdC1-INH dose (U)

No. of patients

No. of attacks

Effectively treated patients

Effectively treated attacks

Non-effectively treated patients

Non-effectively treated attacks

No. of patients

No. of attacks

Effectively treated patients

Effectively treated attacks

Non-effectively treated patients

Non-effectively treated attacks

500

3

338

3

337

1

1

7

102

5

33

3

69

1000

4

8

3

7

1

1

6

907

5

900

3

7

1500

0

0

0

0

0

0

2

4

1

1

1

3

2000

0

0

0

0

0

0

4

315

3

311

1

4

3000

0

0

0

0

0

0

1

1

1

1

0

0

 

-.

346

344

2

2

1329

1246

83

  1. Note: The same patients may be represented as effectively treated and non-effectively treated
  2. C1-INH = C1-inhibitor