Table 3 short- and long-term morbidity
Hazard ratio (95% CI; p-value)#, unadjusted | Hazard ratio (95% CI; p-value)#, adjusted for age at diagnosis and tumor size (microadenoma or macroadenoma) | |
|---|---|---|
Surgical outcome | ||
-Persistent disease | 0.82 (0.34 to 2.01; p = 0.663) | 0.88 (0.35 to 2.21; p = 0.789) |
-Recurrent disease | 0.47 (0.19 to 1.14; p = 0.093) | 0.40 (0.16 to 1.01; p = 0.052) |
-Hydrocortisone dependency - Absolute deficiency - Normal cortisol response* - Pragmatic replacement $ | 1.11 (0.73 to 1.68; p = 0.625) 1.06 (0.69 to 1.62; p = 0.793) | 1.04 (0.68 to 1.60; p = 0.845) 0.97 (0.63 to 1.50; p = 0.888) |
-Repeat surgery -Remission after first repeat surgery | 0.30 (0.13 to 0.70; p = 0.005) 0.21 (0.04 to 1.13; p = 0.069) | 0.27 (0.11 to 0.64; p = 0.003) 0.17 (0.02 to 1.16; p = 0.070) |
Short term morbidity: ≤3 month after first surgery | ||
-Cerebrospinal fluid leakage | ° | ° |
-Meningitis | ° | ° |
-Bleeding, all | 0.56 (0.22 to 1.41; p = 0.221) | 0.56 (0.22 to 1.44; p = 0.227) |
-Bleeding, severe | ° | ° |
-Syndrome of inappropriate antidiuretic hormone release | 0.32 (0.09 to 1.09; p = 0.069) | 0.29 (0.08 to 1.02; p = 0.054)a |
-Diabetes insipidus | 1.04 (0.54 to 1.99; p = 0.904) | 0.96 (0.49 to 1.86; p = 0.901) |
-Anterior pituitary deficiency - one axis - two axes - three axes | 0.76 (0.37 to 1.54; p = 0.444) 0.85 (0.37 to 1.96; p = 0.704) 0.41 (0.09 to 1.83; p = 0.243) | 1.06 (0.51 to 2.22; p = 0.870) 1.18 (0.50 to 2.79; p = 0.708) 0.52 (0.11 to 2.45; p = 0.409) |
-Corticosteroid withdrawal syndrome | 0.39 (0.21 to 0.72; p = 0.003) | 0.38 (0.20 to 0.72; p = 0.003) |
-Cardiovascular morbidity | ° | ° |
Long term morbidity: > 3 months after first surgery | ||
-Anterior pituitary deficiency after 1 year - one axis - two axes - three axes | 0.79 (0.42 to 1.52; p = 0.488) 0.83 (0.38 to 1.83; p = 0.642) 0.65 (0.17 to 2.41; p = 0.517) | 1.03 (0.52 to 2.01; p = 0.056) 1.10 (0.48 to 2.48; p = 0.827) 0.74 (0.19 to 2.89; p = 0.663) |
-Hydrocortisone dependency > 3 years | 1.05 (0.56 to 1.96; p = 0.878) | 1.11 (0.59 to 2.10; p = 0.742) |
-Diabetes insipidus > 3 months | 1.71 (0.68 to 4.29; p = 0.251) | 1.84 (0.72 to 4.69; p = 0.204) |
-Cardiovascular morbidity | 0.37 (0.12 to 1.16; p = 0.088) | 0.43 (0.13 to 1.38; p = 0.155) |
-Hypertension | 0.85 (0.51 to 1.41; p = 0.529) | 0.92 (0.53 to 1.58; p = 0.749) |
-Diabetes mellitus | 0.53 (0.22 to 1.29; p = 0.160) | 0.56 (0.23 to 1.36; p = 0.198) |
-Neuropsychiatric morbidity | 0.14 (0.03 to 0.68; p = 0.015) | 0.15 (0.03 to 0.76; p = 0.022) |