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Table 1 demographic characteristics

From: Microscopic versus endoscopic transsphenoidal surgery in the Leiden cohort treated for Cushing’s disease: surgical outcome, mortality, and complications

 

Microscopic trans-sphenoidal adenomectomy

Endoscopic transsphenoidal adenomectomy

Tested difference (95% CI; p-value)

Tested difference (95% CI; p-value) (Microadenoma only)

Tested difference (95% CI; p-value) (Macroadenoma only)

N

%

N

%

   

Total

87

100.0

50

100.0

 

Sample size:103

Sample size:34

Age at diagnosis, years*

38.9

15.4

44.4

15.1

5.5 (0.1 to 10.9; p = 0.045)

3.4 (−2.6 to 9.3; p = 0.263)

9.0 (−3.5 to 21.4; p = 0.152)

Sex (female)

69

79.3

34

68.0

11.3 (−4.2 to 26.8; p = 0.140)

7.7 (− 10.4 to 25.8; p = 0.391)

20.8 (−8.5 to 50.1; p = 0.170)

Calendar year of transsphenoidal surgery°

1992

1978–2005

2011

2003–2016

19.2 (17.1 to 21.2; p = 0.000)

20.4 (18.1 to 22.6; p = 0.000)

14.7 (10.1 to 19.3; p = 0.000)

Duration of follow-up (years) $

16.9

11.7–26.7

4.7

2.0–7.4

13.4 (11.0 to 15.8; p = 0.000)

14.0 (11.2 to 17.7; p = 0.000)

11.3 (6.9 to 15.6; p = 0.000)

Comorbidities at diagnosis

Hypertension

64

73.6

38

76.0

2.4 (− 12.6 to 17.4; p = 0.756)

3.3 (−15.2 to 21.8; p = 0.723)

15.3 (− 11.0 to 41.6; p = 0.271)

Diabetes mellitus

14

16.1

15

30.0

13.9 (−1.0 to 28.8; p = 0.055)

13.5 (−4.1 to 31.1; p = 0.110)

14.5 (−14.0 to 43.0; p = 0.320)

Dyslipidemia

8

9.1

8

16.0

6.9 (− 4.9 to 18.7; p = 0.225)

3.0 (−8.0 to 14.0; p = 0.569)

9.0 (−20.7 to 38.7; p = 0.553)

Cushing’s syndrome Severity Index score*

6.9

2.3

6.8

2.8

−0.10 (−0.98 to 0.79; p = 0.832)

0.09 (−1.00 to 1.17; p = 0.877)

− 0.72 (−2.31 to 0.86; p = 0.357)

0–4

13

15.1

10

20.0

   

5–8

53

61.6

27

54.0

   

9–16

20

23.2

13

26.0

   

Tumor size

    

11.3 (−4.2 to 26.8; p = 0.140)

Microadenoma

69

79.3

34

68.0

   

Macroadenoma Cavernous sinus invasion

185

20.7 27.8

16 8

32.0 50.0

   

Referral by other neurosurgeon or university medical center

4

4.6

6

12.0

7.4 (−2.6 to 17.4; p = 0.109)

3.0 (−5.9 to 11.9; p = 0.459)

13.9 (−11.8 to 39.6; p = 0.389)

Medical treatment prior to surgery

57

65.5

47

94.0

28.5 (16.5 to 40.5; p = 0.000)

34.8 (23.6 to 46.0; p = 0.000)

14.6 (−14.4 to 43.6; p = 0.335)

-Metyrapone

8

9.2

16

32.0

   

-Ketoconazole

51

58.6

32

64.0

   

-Pasireotide

0

0.0

2

4.0

   
  1. *mean + standard deviation, °mean + range, $median + interquartile range; CI = confidence interval