Intertumor heterogeneity in 60 pancreatic neuroendocrine tumors associated with multiple endocrine neoplasia type 1

Table 2 Proliferation index (Ki-67) and immunohistochemical staining of Islet-1, TTF1 and CDX2

Patient	Function	PNEN	Location	Ki-67 (%)	Islet-1 (%)	TTF1 (%)	CDX2 (%)
A	F (WDHA-syndrome)	1	Head	1	+++	+	–
		2	Body	1	+++	–	–
		3	Tail	2	+++	–	–
B	NF	1	Head	2	+++	–	–
		2	Body	8	+++	–	–
		3		1	+	++	–
		4		1	++	–	–
		5		1	+++	–	–
		6	Tail	1	+++	–	–
C	NF	1	Duodenum	1	+	–	++
		2	Head	1	+++	–	–
		3	Body	1	+++	–	++
		4		2	+++	–	–
		5		1	+++	–	–
		6		1	+++	–	–
		7		1	+++	–	–
		8	Tail	1	+++	–	–
		9		1	+++	–	–
		10		1	+++	–	–
		11		1	+++	–	–
		12		1	+++	–	–
		13		1	+++	–	–
		14		1	+++	–	–
		15		1	+++	–	–
D	F (Hyper-insulinism)	1	Body/Tail	1	+++	–	–
		2		1	+++	–	–
		3		3	+++	–	–
		4		2	+++	–	–
		5		1	+++	–	–
E	NF	1	Head	1	n.f.	n.f.	n.f.
		2	Head	1	+++	–	–
		3	Head/Body	1	+++	–	–
		4		1	+++	–	–
		5		1	+++	–	–
		6		1	+++	–	–
		7		1	+++	–	–
		8	Tail	1	+++	–	–
		9		1	+++	–	–
		10		1	+++	–	–
		11		1	+++	–	–
		12		1	+++	–	–
		13		1	+++	–	–
		14		1	+++	–	–
		15		1	+++	–	–
		16		1	+++	–	–
		17		1	+++	–	–
		18		1	+++	–	–
F	F (subclinical Hyper-insulinism)	1	Head/Body	1	+++	–	–
		2		1	+++	–	–
		3		1	+++	–	–
		4		1	+++	–	–
		5		1	+++	–	–
		6		1	+++	–	–
		7		1	+++	–	–
		8		1	+++	–	–
		9		1	+++	–	–
		10		1	+++	–	–
		11		1	+++	–	–
		12		1	+++	–	–
		13	Tail	1	+++	–	–

ISSN: 1750-1172