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Table 2 Proliferation index (Ki-67) and immunohistochemical staining of Islet-1, TTF1 and CDX2

From: Intertumor heterogeneity in 60 pancreatic neuroendocrine tumors associated with multiple endocrine neoplasia type 1

Patient Function PNEN Location Ki-67 (%) Islet-1 (%) TTF1 (%) CDX2 (%)
A F (WDHA-syndrome) 1 Head 1 +++ +
2 Body 1 +++
3 Tail 2 +++
B NF 1 Head 2 +++
2 Body 8 +++
3 1 + ++
4 1 ++
5 1 +++
6 Tail 1 +++
C NF 1 Duodenum 1 + ++
2 Head 1 +++
3 Body 1 +++ ++
4 2 +++
5 1 +++
6 1 +++
7 1 +++
8 Tail 1 +++
9 1 +++
10 1 +++
11 1 +++
12 1 +++
13 1 +++
14 1 +++
15 1 +++
D F (Hyper-insulinism) 1 Body/Tail 1 +++
2 1 +++
3 3 +++
4 2 +++
5 1 +++
E NF 1 Head 1 n.f. n.f. n.f.
2 1 +++
3 Head/Body 1 +++
4 1 +++
5 1 +++
6 1 +++
7 1 +++
8 Tail 1 +++
9 1 +++
10 1 +++
11 1 +++
12 1 +++
13 1 +++
14 1 +++
15 1 +++
16 1 +++
17 1 +++
18 1 +++
F F (subclinical Hyper-insulinism) 1 Head/Body 1 +++
2 1 +++
3 1 +++
4 1 +++
5 1 +++
6 1 +++
7 1 +++
8 1 +++
9 1 +++
10 1 +++
11 1 +++
12 1 +++
13 Tail 1 +++
  1. Positivity of cells (+: ≤ 10%; ++: > 10 to < 100%; +++: 100%)