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Table 2 Biological metabolic parameters of the whole group and the two subgroups according to the presence of an ultrasound goiter

From: Systematic thyroid screening in myotonic dystrophy: link between thyroid volume and insulin resistance

Metabolic parameters Whole group UsGoiter UsNonGoiter p-value
Number of patients (N; %) N = 115 44 (38.3) 71 (61.7)  
Glucose metabolism
 Abnormal glucose tolerance (n/N; %) 16/112 (14.3) 7/44 (15.9) 9/68 (13.2) .69
 Diabetes (n/N; %) 30/115 (26.1) 10/44 (22.7) 20/70 (28.6) .45
  Insulin therapy 3/46 (6.5) 0/17 3/29 (10.4) .02
  Metformin therapy 9/46 (19.6) 4/17 (23.5) 5/29 (17.2) .12
  Insulin + Metformin 3/46 (6.5) 1/17 (5.9) 2/29 (6.9) .43
  HbA1c (median (IQR); %) 5.5 (5.2–5.8) 5.4 (5.2–5.8) 5.5 (5.3–5.7) .39
OGTT (mean ± SD)
 Glucose T0 (mg/dL) 90.0 ± 15.0 90.0 ± 20.0 90.0 ± 10.0 .60
 Glucose T120 min (mg/dL) 115.0 ± 50.0 140.0 ± 50.0 90.0 ± 50.0 .048
 Insulin T0 (mU/L) 7.4 ± 6.1 8.1 ± 6.9 6.6 ± 5.2 .11
 Insulin T120 min (mU/L) 42.5 ± 37.4 45.8 ± 31.5 39.2 ± 43.2 .051
Lipids (mg/dL)
 Total cholesterol (mean ± SD) 200.0 ± 40.0 200.0 ± 40.0 200.0 ± 40.0 .59
 LDLc (median (IQR)) 117 (96–140) 110 (90–140) 120 (100–140) .96
 HDLc (median (IQR)) 50 (43–59) 50 (40–60) 50 (40–60) .99
 Triglycerides (median (IQR)) 132 (97–192) 140 (110–180) 130 (90–220) .89
Vitamin D
 Median (IQR) (ng/ml) 17 (12–28) 17 (11–28) 18 (13–30) .15
n (< 30 ng/mL)/N (%) 88/115 (76.5) 35/44 (79.5) 53/71 (74.7) .51
  1. Abbreviations: SD standard deviation, IQR interquartile, Us Ultrasound, OGTT Oral glucose tolerance test, LDL Low density lipoprotein, HDL High density lipoprotein