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Table 1 Symptom incidence in each age group and cohort as a whole

From: Early progression of Krabbe disease in patients with symptom onset between 0 and 5 months

  0-3 months (n = 16) 4-6 months (n = 28) 7-9 months (n = 36) 10-12 months (n = 21) 13-17 months (n = 19) 18-23 months (n = 11) >24 months (n = 16)
Symptom N Mean N Mean N Mean N Mean N Mean N Mean N Mean
Reflux 12 17% 26 62% 25 84% 18 61% 8 50% 5 40% 11 45%
Feeding Difficulties or swallowing difficulties 14 7% 28 79% 33 97% 21 90% 16 88% 8 100% 12 100%
Required Suctioning 12 0% 19 11% 28 50% 18 50% 16 81% 11 91% 15 87%
Diarrhea 10 0% 20 25% 20 10% 16 6% 12 0% 6 0% 12 17%
Constipation 10 10% 21 38% 29 59% 18 56% 16 63% 10 70% 16 75%
Visual Tracking Difficulty 14 7% 28 57% 33 58% 19 68% 19 89% 11 64% 16 88%
Jerky eye movements/eye fluttering 13 0% 17 12% 26 27% 19 32% 14 29% 9 78% 13 54%
Nystagmus 12 0% 17 12% 24 0% 18 17% 18 22% 10 20% 14 21%
Hip asymmetry 12 0% 15 7% 25 12% 21 24% 19 47% 11 55% 15 87%
Scoliosis 10 0% 16 13% 28 14% 20 40% 17 65% 10 70% 16 94%
Axial Hypotonia 12 17% 23 65% 30 83% 21 100% 19 100% 11 100% 15 100%
Abnormal DTRs 12 17% 26 88% 31 94% 21 95% 19 100% 11 100% 15 100%
Clasped Thumb/Hand Fisting 12 33% 26 92% 32 94% 20 85% 18 78% 10 60% 15 40%
Appendicular Spasticity 13 8% 24 100% 34 97% 20 90% 19 74% 11 64% 16 75%
Clinical Seizures 10 0% 18 6% 25 8% 20 15% 16 19% 9 33% 15 33%
Staring Episodes 10 0% 17 41% 27 48% 17 41% 14 64% 9 89% 12 92%
Shallow Breathing or Cheyne-Strokes 12 0% 24 17% 30 37% 21 48% 19 79% 11 82% 16 88%
Apneic Episodes 12 0% 17 18% 26 23% 19 32% 17 59% 10 60% 16 63%
Poor Peripheral Perfusion 11 0% 18 0% 24 4% 18 17% 18 44% 10 60% 14 71%
Temperature Instability 14 0% 28 0% 34 6% 21 14% 19 32% 11 55% 16 69%
Abnormal Pupillary Response 11 0% 23 22% 30 43% 19 58% 19 89% 11 100% 14 100%
  1. Displays the incidence of each symptom for patients evaluated between 0 and 3 months, 4–6 months, 7–9 months, 10–12 months, 13–17 months, 18–23 months, and ≥ 24 months. Symptoms with incidence > 50% are bolded. N is the number of patients which exhibited the symptoms at that time point. n is the number of patients that were evaluated for that age range