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Table 1 Clinical features and laboratory features, genetic evaluation and prognosis of 4 patients with PPL

From: Primary pulmonary lymphoma in children

 

Patient 1

Patient 2

Patient 3

Patient 4

Gender

Male

Male

Male

Female

Age

7-years-5-months

5-years-2-months

11-years-1-month

8-years-4-months

Presentation

Intermittent fever, cough

Persistent fever,cough

Persistent fever

Persistent fever

Physical examination

Normal

Normal

Normal

Normal

Past history

History of recurrent pneumonia (At the age of 4 months, 2-years-old, 3-years-old, 6-years-old and 7-years-old)

Normal

History of recurrent respiratory infections (8–10 times per year)

Normal

Underlying disease

I Ligase IV syndrome

Unclear

Immunodeficiency-21

Unclear

Prognosis

Died

Died

Died of respiratory failure after two chemotherapy sessions

Died

WBC(× 109/L)

1.1~6.4

2.1~7.8

2.5~6.7

4.3~8.8

CRP(mg/L)

73~168

5~23

20~118

120~180

PCT (ng/ml)

Normal

Normal

Normal

Normal

Pathological findings

Diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma

NK/T-cell lymphoma

Diffuse large B-cell lymphoma

Immune globulin

IgA < 0.0067 g/L, IgG11.6 g/L, IgM1.12 g/L, IgE0.11 IU/ml

Normal

Normal

Normal

Lymphocyte subsets

NK cells (44.9%), B cell (30.9%); CD4+ cells (6.1%), CD8+ cells (19.6%)

Normal

Normal

Normal

ANA,dsDNA,ACA,ANCA

Normal

Normal

Normal

Normal

Bone marrow examination

Normal

Normal

Normal

Normal

Diagnostic procedure

Open lung biopsy

Open lung biopsy

Open lung biopsy

Thoracscopy lung biopsy

Cytological results of bronchoalveolar lavage fluid

A great number of neutrophils; A small amounts of phagocytes, epithelial cells and lymphocytes;

A great number of neutrophils, A small amounts of histiocytes, epithelial cells and lymphocytes;

A great number of red blood cells and neutrophis; A small amounts of phagocytes, epithelial cells and lymphocytes

Microbiological results of bronchoalveolar lavage fluid

Negative

Streptococcus viridans

Negative

  1. Abbreviations: ANA antinuclear antibody, ACA anticardiolipin antibody, ANCA antineutrophil cytoplasmic antibody, NK natural killer