Patient 1 | Patient 2 | Patient 3 | Patient 4 | |
---|---|---|---|---|
Gender | Male | Male | Male | Female |
Age | 7-years-5-months | 5-years-2-months | 11-years-1-month | 8-years-4-months |
Presentation | Intermittent fever, cough | Persistent fever,cough | Persistent fever | Persistent fever |
Physical examination | Normal | Normal | Normal | Normal |
Past history | History of recurrent pneumonia (At the age of 4 months, 2-years-old, 3-years-old, 6-years-old and 7-years-old) | Normal | History of recurrent respiratory infections (8–10 times per year) | Normal |
Underlying disease | I Ligase IV syndrome | Unclear | Immunodeficiency-21 | Unclear |
Prognosis | Died | Died | Died of respiratory failure after two chemotherapy sessions | Died |
WBC(× 109/L) | 1.1~6.4 | 2.1~7.8 | 2.5~6.7 | 4.3~8.8 |
CRP(mg/L) | 73~168 | 5~23 | 20~118 | 120~180 |
PCT (ng/ml) | Normal | Normal | Normal | Normal |
Pathological findings | Diffuse large B-cell lymphoma | Diffuse large B-cell lymphoma | NK/T-cell lymphoma | Diffuse large B-cell lymphoma |
Immune globulin | IgA < 0.0067 g/L, IgG11.6 g/L, IgM1.12 g/L, IgE0.11 IU/ml | Normal | Normal | Normal |
Lymphocyte subsets | NK cells (44.9%), B cell (30.9%); CD4+ cells (6.1%), CD8+ cells (19.6%) | Normal | Normal | Normal |
ANA,dsDNA,ACA,ANCA | Normal | Normal | Normal | Normal |
Bone marrow examination | Normal | Normal | Normal | Normal |
Diagnostic procedure | Open lung biopsy | Open lung biopsy | Open lung biopsy | Thoracscopy lung biopsy |
Cytological results of bronchoalveolar lavage fluid | – | A great number of neutrophils; A small amounts of phagocytes, epithelial cells and lymphocytes; | A great number of neutrophils, A small amounts of histiocytes, epithelial cells and lymphocytes; | A great number of red blood cells and neutrophis; A small amounts of phagocytes, epithelial cells and lymphocytes |
Microbiological results of bronchoalveolar lavage fluid | – | Negative | Streptococcus viridans | Negative |