Skip to main content

Table 1 Clinical features and laboratory features, genetic evaluation and prognosis of 4 patients with PPL

From: Primary pulmonary lymphoma in children

  Patient 1 Patient 2 Patient 3 Patient 4
Gender Male Male Male Female
Age 7-years-5-months 5-years-2-months 11-years-1-month 8-years-4-months
Presentation Intermittent fever, cough Persistent fever,cough Persistent fever Persistent fever
Physical examination Normal Normal Normal Normal
Past history History of recurrent pneumonia (At the age of 4 months, 2-years-old, 3-years-old, 6-years-old and 7-years-old) Normal History of recurrent respiratory infections (8–10 times per year) Normal
Underlying disease I Ligase IV syndrome Unclear Immunodeficiency-21 Unclear
Prognosis Died Died Died of respiratory failure after two chemotherapy sessions Died
WBC(× 109/L) 1.1~6.4 2.1~7.8 2.5~6.7 4.3~8.8
CRP(mg/L) 73~168 5~23 20~118 120~180
PCT (ng/ml) Normal Normal Normal Normal
Pathological findings Diffuse large B-cell lymphoma Diffuse large B-cell lymphoma NK/T-cell lymphoma Diffuse large B-cell lymphoma
Immune globulin IgA < 0.0067 g/L, IgG11.6 g/L, IgM1.12 g/L, IgE0.11 IU/ml Normal Normal Normal
Lymphocyte subsets NK cells (44.9%), B cell (30.9%); CD4+ cells (6.1%), CD8+ cells (19.6%) Normal Normal Normal
ANA,dsDNA,ACA,ANCA Normal Normal Normal Normal
Bone marrow examination Normal Normal Normal Normal
Diagnostic procedure Open lung biopsy Open lung biopsy Open lung biopsy Thoracscopy lung biopsy
Cytological results of bronchoalveolar lavage fluid A great number of neutrophils; A small amounts of phagocytes, epithelial cells and lymphocytes; A great number of neutrophils, A small amounts of histiocytes, epithelial cells and lymphocytes; A great number of red blood cells and neutrophis; A small amounts of phagocytes, epithelial cells and lymphocytes
Microbiological results of bronchoalveolar lavage fluid Negative Streptococcus viridans Negative
  1. Abbreviations: ANA antinuclear antibody, ACA anticardiolipin antibody, ANCA antineutrophil cytoplasmic antibody, NK natural killer