Disease progression in women with X-linked adrenoleukodystrophy is slow

Table 3 Clinical validity – symptomatic and asymptomatic

	N	U	Symptomatic		Asymptomatic		P value
	N	U	N	Mean Rank	N	Mean rank	P value
EDSS	63	929.000	37	44.11	26	14.77	< 0.0005 *
ALDS	64	231.000	36	24.92	28	42.25	< 0.0005 *
SF-36: Physical functioning	64	294.500	36	26.68	28	39.98	0.005 *
SF-36: Role physical	64	379.500	36	29.04	28	36.95	0.09
SF-36: Bodily pain	64	360.000	36	28.50	28	37.64	0.051
SF-36: General health perceptions	64	370.000	36	28.78	28	37.29	0.070
SF-36: Vitality	63	512.000	35	32.63	28	31.21	0.761
SF-36: Social functioning	64	496.000	36	32.28	28	32.79	0.914
SF-36: Role emotional	64	588.000	36	34.83	28	29.50	0.249
SF-36: Mental health	63	517.000	35	32.77	28	31.04	0.709
SF-36: Physical component summary	63	282.000	35	26.06	28	39.43	0.004 *
SF-36: Mental component summary	63	614.000	35	35.54	28	27.57	0.086

Mann-Whitney U tests were run to assess if there were differences in scores between symptomatic and asymptomatic women at baseline. * indicates a significant p value. ALDS = AMC Linear Disability Scale; EDSS = Expanded Disability Status Scale; N = number of patients; Role emotional = role limitations due to emotional problems; Role physical = role limitations due to physical problems; SF-36 = Short Form (36) Health Survey; U = Mann-Whitney U statistic

ISSN: 1750-1172