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Table 3 PROMIS Instrument Analysis

From: Assessing disease experience across the life span for individuals with osteogenesis imperfecta: challenges and opportunities for patient-reported outcomes (PROs) measurement: a pilot study

Testing Population

PROMIS® Measure

N

Mean (t-score)

Std Dev

95% CI of the Mean

Mean Significantly Different than 50 (p-value)?

Adult

Anxiety

193

55.98

8.72

(54.74, 57.22)

Yes (p < 0.001)

Depression

192

53.19

9.63

(51.82, 54.56)

Yes ( p  < 0.001)

Fatigue

190

54.68

9.44

(53.33, 56.03)

Yes ( p  < 0.001)

Pain Behavior

190

54.79

8.30

(53.60, 55.97)

Yes (p < 0.001)

Pain Interference

188

57.50

9.64

(56.12, 58.89)

Yes (p < 0.001)

Physical Function

102

43.91

7.48

(42.44, 45.38)

Yes ( p  < 0.001)

Physical Function with Mobility Aid

85

35.82

6.13

(34.50, 37.14)

Yes ( p  < 0.001)

Sleep Disturbance

188

53.19

9.15

(51.88, 54.51)

Yes ( p  < 0.001)

Satisfaction with Participation in Social Roles

186

47.42

9.58

(46.03, 48.80)

Yes ( p  < 0.001)

Parent Proxy

Anxiety

56

54.91

9.91

(52.25, 57.56)

Yes ( p  < 0.001)

Depressive Symptoms

54

50.60

9.12

(48.11, 53.09)

No (p = 0.580)

Fatigue

52

50.85

12.00

(47.51, 54.19)

No (p = 0.590)

Pain Interference

51

54.08

8.91

(51.57, 56.58)

Yes (p = 0.004)

Mobility

52

33.98

11.44

(30.79, 37.16)

Yes ( p  < 0.001)

Peer Relationships

52

42.09

10.85

(39.07, 45.11)

Yes ( p  < 0.001)

  1. * Bold means p < 0.001