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Fig. 4 | Orphanet Journal of Rare Diseases

Fig. 4

From: Profiling of patient-specific myocytes identifies altered gene expression in the ophthalmoplegic subphenotype of myasthenia gravis

Fig. 4

MG sera induces gene expression changes in patient-derived myocytes. RNA was extracted from untreated and MG sera (MGS) treated control MG (n = 6) and OP-MG (n = 10) myocytes after 48 h differentiation as described. Target gene expression levels were determined using the custom qPCR gene expression array and a fold change in gene expression was calculated (MG sera treated/untreated) for each gene following normalization. Genes with statistically significant (p < 0.05) fold changes (> 1.5 up or downregulated) for both control MG and OP-MG are shown. Error bars show mean and 95% CI. Student’s paired t-test was used to compare gene expression levels (MGS vs untreated) for each subphenotype. *p < 0.05, ** p < 0.01, *** p < 1 × 10− 3. 1 datapoint has been excluded from the graph as it lies beyond the y-axis limits

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172