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Table 2 Age-stratified unadjusted relative (rate ratio) and absolute (rate difference) comparisons of rates of health services encounters in MCAD deficiency cohort versus screen negative cohort

From: Health services use among children diagnosed with medium-chain acyl-CoA dehydrogenase deficiency through newborn screening: a cohort study in Ontario, Canada

Outcome and age group Incidence rate ratio (IRR), MCAD deficiency cohort vs. screen negative cohort (95% CI) Incidence rate difference (IRD), MCAD deficiency cohort vs. screen negative cohort, per child per year (95% CI)
Physician encounters
  < 6 months 1.2 (1.1, 1.3) 4.2 (2.1, 6.4)
 6 to < 12 months 1.6 (1.4, 1.8) 5.8 (4.1, 7.5)
 12 to < 18 months 1.3 (1.1, 1.5) 2.9 (1.3, 4.5)
 18 to < 24 months 1.7 (1.5, 1.9) 5.0 (3.4, 6.6)
 2 to < 3 years 1.4 (1.2, 1.5) 2.0 (1.1, 2.9)
 3 to < 4 years 1.5 (1.3, 1.7) 2.4 (1.3, 3.4)
  ≥ 4 years 1.5 (1.3, 1.7) 2.5 (1.4, 3.6)
Emergency department visits
  < 6 months 1.9 (1.3, 2.7) 0.7 (0.2, 1.2)
 6 to < 12 months 3.1 (2.4, 4.1) 1.7 (1.0, 2.4)
 12 to < 18 months 2.6 (2.0, 3.5) 1.4 (0.8, 2.1)
 18 to < 24 months 2.7 (2.0, 3.7) 1.3 (0.7, 2.0)
 2 to < 3 years 2.1 (1.6, 2.9) 0.7 (0.3, 1.1)
 3 to < 4 years 2.0 (1.4, 3.0) 0.5 (0.1, 0.9)
  ≥ 4 years 1.7 (1.1, 2.6) 0.3 (−0.03, 0.7)a
Inpatient hospitalizations
  < 6 months 1.6 (0.8, 3.5)a 0.1 (− 0.1, 0.4)a
 6 to < 12 months 10.8 (6.1, 18.9) 0.5 (0.2, 0.9)
 12 to < 24 months 9.6 (6.1, 15.0) 0.4 (0.2, 0.6)
 2 to < 3 years 10.8 (6.3, 18.7) 0.3 (0.1, 0.5)
  ≥ 3 years 15.2 (9.7, 23.8) 0.4 (0.2, 0.5)
  1. aDifference not statistically significant, p > 0.05; all other rates were statistically significantly different between the two cohorts