|
Outcome and age group
|
Incidence rate ratio (IRR), MCAD deficiency cohort vs. screen negative cohort (95% CI)
|
Incidence rate difference (IRD), MCAD deficiency cohort vs. screen negative cohort, per child per year (95% CI)
|
|---|
|
Physician encounters
|
|
< 6 months
|
1.2 (1.1, 1.3)
|
4.2 (2.1, 6.4)
|
|
6 to < 12 months
|
1.6 (1.4, 1.8)
|
5.8 (4.1, 7.5)
|
|
12 to < 18 months
|
1.3 (1.1, 1.5)
|
2.9 (1.3, 4.5)
|
|
18 to < 24 months
|
1.7 (1.5, 1.9)
|
5.0 (3.4, 6.6)
|
|
2 to < 3 years
|
1.4 (1.2, 1.5)
|
2.0 (1.1, 2.9)
|
|
3 to < 4 years
|
1.5 (1.3, 1.7)
|
2.4 (1.3, 3.4)
|
|
≥ 4 years
|
1.5 (1.3, 1.7)
|
2.5 (1.4, 3.6)
|
|
Emergency department visits
|
|
< 6 months
|
1.9 (1.3, 2.7)
|
0.7 (0.2, 1.2)
|
|
6 to < 12 months
|
3.1 (2.4, 4.1)
|
1.7 (1.0, 2.4)
|
|
12 to < 18 months
|
2.6 (2.0, 3.5)
|
1.4 (0.8, 2.1)
|
|
18 to < 24 months
|
2.7 (2.0, 3.7)
|
1.3 (0.7, 2.0)
|
|
2 to < 3 years
|
2.1 (1.6, 2.9)
|
0.7 (0.3, 1.1)
|
|
3 to < 4 years
|
2.0 (1.4, 3.0)
|
0.5 (0.1, 0.9)
|
|
≥ 4 years
|
1.7 (1.1, 2.6)
|
0.3 (−0.03, 0.7)a
|
|
Inpatient hospitalizations
|
|
< 6 months
|
1.6 (0.8, 3.5)a
|
0.1 (− 0.1, 0.4)a
|
|
6 to < 12 months
|
10.8 (6.1, 18.9)
|
0.5 (0.2, 0.9)
|
|
12 to < 24 months
|
9.6 (6.1, 15.0)
|
0.4 (0.2, 0.6)
|
|
2 to < 3 years
|
10.8 (6.3, 18.7)
|
0.3 (0.1, 0.5)
|
|
≥ 3 years
|
15.2 (9.7, 23.8)
|
0.4 (0.2, 0.5)
|
- aDifference not statistically significant, p > 0.05; all other rates were statistically significantly different between the two cohorts
