Table 3 Individual MPS I patients – kyphosis surgery
Study | Patient ID (as reported in article) | Age at surgery (years) | Apex | Surgical approach | Levels of fusion | Kyphotic angle Preoperative/postoperative | Complications | Angle at follow-up | Follow-up (years) |
|---|---|---|---|---|---|---|---|---|---|
Abelin Genevois, JIMD, 2014 [17] | 1 | 8.5 | L1 | Anteroposterior (circumferential) arthrodesis | T10-L4; corp T12-L2 | 70°/30° | Sylvian infarction | −29° | 1 |
Abelin Genevois, JIMD, 2014 [17] | 2 | 12 | L1 L2 | Posterior only arthrodesis; Anteroposterior (circumferential) arthrodesis | T11-L3 | 60°/13° | Adjacent segment listhesis: revision | 21° | 1.9 |
Abelin Genevois, JIMD, 2014 [17] | 3 | 7.5 | L2 L3 | Anteroposterior (circumferential) arthrodesis | T11-L4 | 90°/− | Cardio-respiratory failure | Not reported (NR) | NR |
Abelin Genevois, JIMD, 2014 [17] | 4 | 8 | L1 L2 | Anteroposterior (circumferential) arthrodesis | T9-L3; corp T11-T12 | 50°/6° | Adjacent segment listhesis | 39° | 8.3 |
Abelin Genevois, JIMD, 2014 [17] | 5 | 3.5 | L1 | Posterior only arthrodesis; Anteroposterior (circumferential) arthrodesis | T12-L5; corp L2-L3 | 90°/− | Adjacent segment listhesis: hip luxation | NR | 3.5 |
Abelin Genevois, JIMD, 2014 [17] | 6 | 15 | L2 L3 | Anteroposterior (circumferential) arthrodesis | T12-L5; corp L2-L3 | 65°/45° | Transient paraparesis | NR | 2 |
Abelin Genevois, JIMD, 2014 [17] | 7 | 9 | L2 | Anteroposterior (circumferential) arthrodesis | T11-L1; corp T1 | 45°/10° | No | 20° | 1.8 |
Abelin Genevois, JIMD, 2014 [17] | 8 | 6 | L3 | Anteroposterior (circumferential) arthrodesis | L1-L4; corp L2-L3 | 30°/−4° | No | −10° | 7.2 |
Abelin Genevois, JIMD, 2014 [17] | 9 | 4.5 | T12 | Anteroposterior (circumferential) arthrodesis | T12-L3 | 84°/42° | Progressive scoliosis | −28° | 0.9 |
Abelin Genevois, JIMD, 2014 [17] | 10 | 9 | L2 | Anteroposterior (circumferential) arthrodesis | L1-L3; corp L2 | 35°/13° | No | 21° | 2.4 |
Abelin Genevois, JIMD, 2014 [17] | 11 | 8.5 | L2 | Anteroposterior (circumferential) arthrodesis | T12-L3; corp L2 | 30°/−14° | No | 25° | 0.8 |
Abelin Genevois, JIMD, 2014 [17] | 12 | 5 | L2 | Anteroposterior (circumferential) arthrodesis | T11-L3; corp T12-L2 | 34°/−10° | No | 25° | 6.3 |
Abelin Genevois, JIMD, 2014 [17] | 13 | 5 | L2 | Anteroposterior (circumferential) arthrodesis | T12-L3 | 70°/52° | Hip dislocation | −22° | 8.7 |
Roberts et al., Bone Joint J, 2016 [52] | 7 | 6.8 | T12 | Circumferential arthrodesis | T10-L3 | 110°/65° | No | NR | 7.2 |
Roberts et al., Bone Joint J, 2016 [52] | 8 | 7.7 | L1 | Circumferential arthrodesis | T10-L4 | 94°/65° | No | NR | 9.3 |
Roberts et al., Bone Joint J, 2016 [52] | 9 | 16.8 | L1 | Circumferential arthrodesis with posterior instrumentation | T10-L5 | 78°/35° | No | NR | 4.6 |
Roberts et al., Bone Joint J, 2016 [52] | 10 | 2.8 | L2 | Circumferential arthrodesis with posterior instrumentation | T11-L4 | 56°/0° | Deep wound infection; stable 3.5proximal junctional kyphosis | NR | 3.5 |
Roberts et al., Bone Joint J, 2016 [52] | 11 | 4.1 | L1-L2 | Circumferential arthrodesis | T10-L4 | 110°/55° | No | NR | 6.6 |
Roberts et al., Bone Joint J, 2016 [52] | 12 | 3.1 | T12 | Circumferential arthrodesis with posterior instrumentation | T10-L3 | 62°/22° | No | NR | 5.1 |
Roberts et al., Bone Joint J, 2016 [52] | 13 | 3.4 | L1-L2 | Circumferential arthrodesis with posterior instrumentation | T12-L2 | 69°/12° | No | NR | 5.8 |
Yasin et al., Spine, 2014 | 10 | Combined anterior and posterior instrumented fusion | NR | 84° | NR | 36° | 0.5 | ||
Yasin et al., Spine, 2014 | 4 | VEPTR | NR | 87° | NR | 35° | 1 | ||
Tandon et al., J Bone Joint Surg, 1996 [30] | 1 | 2.8 | L2 | Posterior spinal fusion | L1-L3 | 80°/NR | NR | NR | NR |
Tandon et al., J Bone Joint Surg, 1996 [30] | 5 | 10.3 | L2 | Posterior spinal fusion | NR | 56°/NR | NR | NR | NR |
Tandon et al., J Bone Joint Surg, 1996 [30] | 7 | 3.5 | NR | Posterior spinal fusion | NR | 40°/NR | At age 12y symptomatic cord compression at T10-T11 | NR | NR |
Garrido et al., Eur Spine J, 2014 [53] | 2 | 2.4 | L1 | Anterior and posterior spinal arthrodesis with segmental pedicle screw instrumentation | T10-L3 | 70°/ 13° at follow up | Left lower lobe collapse after extubation | 13° | NR |
Garrido et al., Eur Spine J, 2014 [53] | 3 | 3 | T12 | Anterior and posterior spinal arthrodesis with segmental pedicle screw instrumentation | T10-L3 | 63°/13° at follow up | No | 13° | NR |
Garrido et al., Eur Spine J, 2014 [53] | 4 | 2.9 | L1 | Anterior and posterior spinal arthrodesis with segmental pedicle screw instrumentation | T10-L3 | 65°/12° at follow up | Wound-infection | 12° | NR |
Polgreen et al., Bone Marrow Transplantation, 2009 [55] | 3 | NR | NR | Spinal fusion | T9- L3 | NR | NR | NR | NR |
Polgreen et al., Bone Marrow Transplantation, 2009 [55] | 5 | NR | NR | Anteroposterior fusion | T10-L2 | NR | NR | NR | NR |
Polgreen et al., Bone Marrow Transplantation, 2009 [55] | 6 | 5 | NR | Posterior spinal fusion | NR | NR | Progression of kyphosis adjacent to previous fusion T1-T8 | NR | NR |
Polgreen et al., Bone Marrow Transplantation, 2009 [55] | 7 | NR | NR | Spinal fusion | T11-L3 | NR | NR | NR | NR |
Polgreen et al., Bone Marrow Transplantation, 2009 [55] | 8 | NR | NR | Posterior spinal fusion | T7-L3 | NR | NR | NR | NR |
Schmidt et al., Orphanet Journal of Rare diseases, 2016 [33] | 15 | 7.8 | NR | Posterior fusion | NR | 90/NR | NR | NR | NR |
Schmidt et al., Orphanet Journal of Rare diseases, 2016 [33] | 19 | 14.3 | NR | Posterior fusion | NR | NR | NR | NR | NR |
Malm et al., Acta Paediatrica, 2008 [57] | A | NR | NR | Spinal fusion between T8 and L4 | NR | NR | NR | NR | NR |
Malm et al., Acta Paediatrica, 2008 [57] | B | NR | NR | Posterior spinal fusion of T10 to L4 and ventral spinal fusion of T12 to L3 | NR | NR | NR | NR | NR |
Hopwood et al., JIMD, 1993 [56] | P.F. | 7 | NR | Posterior spinal fusion | NR | NR | NR | NR | NR |
Hopwood et al., JIMD, 1993 [56] | E.H. | 10.3 | NR | Posterior spinal fusion using the patient’s own left anterior iliac spine plus donor bone | NR | NR | NR | NR | NR |
Souillet et al., Bone marrow transplantation, 2003 [58] | 1 | 11.2 and 12.2 | NR | Posterior spinal fusion and anterior spinal fusion | NR | NR | NR | NR | NR |
Souillet et al., Bone marrow transplantation, 2003 [58] | 12 | 3.4 | NR | Posterior spinal fusion | NR | NR | NR | NR | NR |
Stoop et al., JIMD reports, 2012 [45] | 5 | NR | NR | Short segment posterior fusion after pedicle subtraction osteotomy of L1 | Th12 - L3 | 80°/ 12° | Kyphosis superior to the spondylodesis: 64° | NR | 1.1 |
Yasuda et al., MGM reports, 2015 [59] | – | 13 | L2 | Spinal fusion | T5-L3 | NR | NR | NR | NR |
Bekmez et al., J Pediatr Orthop,2016 [43] | 3 | 8 | L1 | Posterior fusion | T10-L3 | 52°/15° | Distal junctional kyphosis | 17 | 5.1 |
Makler et al., Surg Neurol Int, 2017 [60] | – | 6 | L1 | Anterior release and posterior spinal fusion | NR | NR | NR | Complete resolution | 3 |
Dalvie et al., Spine,2001 [44] | 7 | 5 | NR | Anterior instrumented correction and fusion | T11-L2 | 59°/18° | No | NR | 0.4 |
Pauchard et al., JIMD reports, 2014 [61] | 2 | 4 | T12 | Planned two-stage surgical correction, with initial posterior instrumentation of T12-L2, followed by anterior graft. After posterior surgery a complication➔ leading to removal of the hardware | T12-L2 | 90°/NR | Asymmetric paraplegia with partial sensory loss, requiring emergency surgery to remove the hardware | NR | NR |