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Table 3 Individual MPS I patients – kyphosis surgery

From: Treatment of thoracolumbar kyphosis in patients with mucopolysaccharidosis type I: results of an international consensus procedure

Study Patient ID (as reported in article) Age at surgery (years) Apex Surgical approach Levels of fusion Kyphotic angle
Preoperative/postoperative
Complications Angle at follow-up Follow-up (years)
Abelin Genevois, JIMD, 2014 [17] 1 8.5 L1 Anteroposterior (circumferential) arthrodesis T10-L4; corp T12-L2 70°/30° Sylvian infarction −29° 1
Abelin Genevois, JIMD, 2014 [17] 2 12 L1 L2 Posterior only arthrodesis; Anteroposterior (circumferential) arthrodesis T11-L3 60°/13° Adjacent segment listhesis: revision 21° 1.9
Abelin Genevois, JIMD, 2014 [17] 3 7.5 L2 L3 Anteroposterior (circumferential) arthrodesis T11-L4 90°/− Cardio-respiratory failure Not reported (NR) NR
Abelin Genevois, JIMD, 2014 [17] 4 8 L1 L2 Anteroposterior (circumferential) arthrodesis T9-L3; corp T11-T12 50°/6° Adjacent segment listhesis 39° 8.3
Abelin Genevois, JIMD, 2014 [17] 5 3.5 L1 Posterior only arthrodesis; Anteroposterior (circumferential) arthrodesis T12-L5; corp L2-L3 90°/− Adjacent segment listhesis: hip luxation NR 3.5
Abelin Genevois, JIMD, 2014 [17] 6 15 L2 L3 Anteroposterior (circumferential) arthrodesis T12-L5; corp L2-L3 65°/45° Transient paraparesis NR 2
Abelin Genevois, JIMD, 2014 [17] 7 9 L2 Anteroposterior (circumferential) arthrodesis T11-L1; corp T1 45°/10° No 20° 1.8
Abelin Genevois, JIMD, 2014 [17] 8 6 L3 Anteroposterior (circumferential) arthrodesis L1-L4; corp L2-L3 30°/−4° No −10° 7.2
Abelin Genevois, JIMD, 2014 [17] 9 4.5 T12 Anteroposterior (circumferential) arthrodesis T12-L3 84°/42° Progressive scoliosis −28° 0.9
Abelin Genevois, JIMD, 2014 [17] 10 9 L2 Anteroposterior (circumferential) arthrodesis L1-L3; corp L2 35°/13° No 21° 2.4
Abelin Genevois, JIMD, 2014 [17] 11 8.5 L2 Anteroposterior (circumferential) arthrodesis T12-L3; corp L2 30°/−14° No 25° 0.8
Abelin Genevois, JIMD, 2014 [17] 12 5 L2 Anteroposterior (circumferential) arthrodesis T11-L3; corp T12-L2 34°/−10° No 25° 6.3
Abelin Genevois, JIMD, 2014 [17] 13 5 L2 Anteroposterior (circumferential) arthrodesis T12-L3 70°/52° Hip dislocation −22° 8.7
Roberts et al., Bone Joint J, 2016 [52] 7 6.8 T12 Circumferential arthrodesis T10-L3 110°/65° No NR 7.2
Roberts et al., Bone Joint J, 2016 [52] 8 7.7 L1 Circumferential arthrodesis T10-L4 94°/65° No NR 9.3
Roberts et al., Bone Joint J, 2016 [52] 9 16.8 L1 Circumferential arthrodesis with posterior instrumentation T10-L5 78°/35° No NR 4.6
Roberts et al., Bone Joint J, 2016 [52] 10 2.8 L2 Circumferential arthrodesis with posterior instrumentation T11-L4 56°/0° Deep wound infection; stable 3.5proximal junctional kyphosis NR 3.5
Roberts et al., Bone Joint J, 2016 [52] 11 4.1 L1-L2 Circumferential arthrodesis T10-L4 110°/55° No NR 6.6
Roberts et al., Bone Joint J, 2016 [52] 12 3.1 T12 Circumferential arthrodesis with posterior instrumentation T10-L3 62°/22° No NR 5.1
Roberts et al., Bone Joint J, 2016 [52] 13 3.4 L1-L2 Circumferential arthrodesis with posterior instrumentation T12-L2 69°/12° No NR 5.8
Yasin et al., Spine, 2014   10   Combined anterior and posterior instrumented fusion NR 84° NR 36° 0.5
Yasin et al., Spine, 2014   4   VEPTR NR 87° NR 35° 1
Tandon et al., J Bone Joint Surg, 1996 [30] 1 2.8 L2 Posterior spinal fusion L1-L3 80°/NR NR NR NR
Tandon et al., J Bone Joint Surg, 1996 [30] 5 10.3 L2 Posterior spinal fusion NR 56°/NR NR NR NR
Tandon et al., J Bone Joint Surg, 1996 [30] 7 3.5 NR Posterior spinal fusion NR 40°/NR At age 12y symptomatic cord compression at T10-T11 NR NR
Garrido et al., Eur Spine J, 2014 [53] 2 2.4 L1 Anterior and posterior spinal arthrodesis with segmental pedicle screw instrumentation T10-L3 70°/ 13° at follow up Left lower lobe collapse after extubation 13° NR
Garrido et al., Eur Spine J, 2014 [53] 3 3 T12 Anterior and posterior spinal arthrodesis with segmental pedicle screw instrumentation T10-L3 63°/13° at follow up No 13° NR
Garrido et al., Eur Spine J, 2014 [53] 4 2.9 L1 Anterior and posterior spinal arthrodesis with segmental pedicle screw instrumentation T10-L3 65°/12° at follow up Wound-infection 12° NR
Polgreen et al., Bone Marrow Transplantation, 2009 [55] 3 NR NR Spinal fusion T9- L3 NR NR NR NR
Polgreen et al., Bone Marrow Transplantation, 2009 [55] 5 NR NR Anteroposterior fusion T10-L2 NR NR NR NR
Polgreen et al., Bone Marrow Transplantation, 2009 [55] 6 5 NR Posterior spinal fusion NR NR Progression of kyphosis adjacent to previous fusion T1-T8 NR NR
Polgreen et al., Bone Marrow Transplantation, 2009 [55] 7 NR NR Spinal fusion T11-L3 NR NR NR NR
Polgreen et al., Bone Marrow Transplantation, 2009 [55] 8 NR NR Posterior spinal fusion T7-L3 NR NR NR NR
Schmidt et al., Orphanet Journal of Rare diseases, 2016 [33] 15 7.8 NR Posterior fusion NR 90/NR NR NR NR
Schmidt et al., Orphanet Journal of Rare diseases, 2016 [33] 19 14.3 NR Posterior fusion NR NR NR NR NR
Malm et al., Acta Paediatrica, 2008 [57] A NR NR Spinal fusion between T8 and L4 NR NR NR NR NR
Malm et al., Acta Paediatrica, 2008 [57] B NR NR Posterior spinal fusion of T10 to L4 and ventral spinal fusion of T12 to L3 NR NR NR NR NR
Hopwood et al., JIMD, 1993 [56] P.F. 7 NR Posterior spinal fusion NR NR NR NR NR
Hopwood et al., JIMD, 1993 [56] E.H. 10.3 NR Posterior spinal fusion using the patient’s own left anterior iliac spine plus donor bone NR NR NR NR NR
Souillet et al., Bone marrow transplantation, 2003 [58] 1 11.2 and 12.2 NR Posterior spinal fusion and anterior spinal fusion NR NR NR NR NR
Souillet et al., Bone marrow transplantation, 2003 [58] 12 3.4 NR Posterior spinal fusion NR NR NR NR NR
Stoop et al., JIMD reports, 2012 [45] 5 NR NR Short segment posterior fusion after pedicle subtraction osteotomy of L1 Th12 - L3 80°/ 12° Kyphosis superior to the spondylodesis: 64° NR 1.1
Yasuda et al., MGM reports, 2015 [59] 13 L2 Spinal fusion T5-L3 NR NR NR NR
Bekmez et al., J Pediatr Orthop,2016 [43] 3 8 L1 Posterior fusion T10-L3 52°/15° Distal junctional kyphosis 17 5.1
Makler et al., Surg Neurol Int, 2017 [60] 6 L1 Anterior release and posterior spinal fusion NR NR NR Complete resolution 3
Dalvie et al., Spine,2001 [44] 7 5 NR Anterior instrumented correction and fusion T11-L2 59°/18° No NR 0.4
Pauchard et al., JIMD reports, 2014 [61] 2 4 T12 Planned two-stage surgical correction, with initial posterior instrumentation of T12-L2, followed by anterior graft. After posterior surgery a complication➔ leading to removal of the hardware T12-L2 90°/NR Asymmetric paraplegia with partial sensory loss, requiring emergency surgery to remove the hardware NR NR