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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: Tracking sex-dependent differences in a mouse model of CLN6-Batten disease

Fig. 3

Sex differences evident in Cln6nclf behavior and survival outcomes. a Female Cln6nclf mice perform more poorly at the rotarod motor task beginning at six months of age. Male Cln6nclf mice do not begin to perform poorly until 10 months of age. b Female Cln6nclf mice perform more poorly at the Morris water maze task beginning at nine months of age. Male Cln6nclf mice do not begin to perform poorly until 11 months of age. c Swim speed shown as a control for the Morris water maze task. d Female Cln6nclf mice perish one month earlier than male Cln6nclf mice. Asterisks (*) show comparisons between wild-type and Cln6nclf animals, with light blue for female comparisons and dark blue for male comparisons. Hash signs (#) show comparisons between male and female Cln6nclf animals. N = 3–10, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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