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Table 1 Number of trials and trial characteristics for all data

From: Estimating the clinical cost of drug development for orphan versus non-orphan drugs

  Non-Orphan Orphan
Phase Phase
Missing 1 2 3 Total Missing 1 2 3 Total
Number of trials 57 95 94 315 561 123 122 204 153 602
Proportion (%) 10.16 16.93 16.76 56.15 100.00 20.43 20.27 33.89 25.42 100.00
Sex
 Missing 56 38 37 126 257 111 37 57 24 229
 Both 1 40 53 175 269 11 81 134 123 349
 Female 0 3 3 13 19 0 2 11 6 19
 Male 0 14 1 1 16 1 2 2 0 5
Age
 Missing 56 38 37 126 257 111 37 57 24 229
 Adult 0 44 15 26 85 2 8 8 0 18
 Adult | Senior 0 11 37 136 184 4 63 93 91 251
 Child 0 1 2 4 7 1 1 2 6 10
 Child | Adult 0 0 0 1 1 0 5 8 4 17
 Child | Adult | Senior 1 1 3 22 27 5 8 36 28 77
Funder Type
 Missing 56 38 37 126 257 111 37 57 24 229
 Industry 0 52 55 181 288 3 53 87 106 249
 Industry | NIH 0 0 0 0 0 0 0 1 1 2
 Industry | NIH | Other 0 1 0 0 1 0 1 3 0 4
 Industry | Other 0 3 0 2 5 0 4 18 4 26
 NIH 0 1 0 4 5 0 10 14 3 27
 NIH |Other 0 0 0 0 0 4 11 8 3 26
 NIH | U.S.Fed 0 0 0 0 0 0 0 0 1 1
 Other 1 0 2 2 5 5 6 16 11 38
Study Start
 Missing 55 40 42 123 260 40 40 42 28 150
 1981 – 1985 0 0 1 0 1 3 0 0 0 3
 1986 – 1990 0 0 0 3 3 7 0 3 1 11
 1991 - 1995 0 0 1 1 2 30 3 5 9 47
 1996 - 2000 1 1 4 25 31 21 8 26 15 70
 2001 - 2005 0 24 17 73 114 18 27 77 60 182
 2006 - 2010 1 21 15 55 92 1 28 28 26 83
 2011 - 2015 0 9 14 35 58 3 16 23 14 56
  1. Note: All values reflect number of trials unless otherwise specified. NIH = National Institutes of Health