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Table 1 Base case and sensitivity analysis by geographic area (sensitivity analysis includes only studies with birth prevalence estimates derived from newborn screening studies) (detection rate per 100,000 newborns)

From: Systematic literature review and meta-analysis on the epidemiology of propionic acidemia

  Base case Sensitivity analysis (birth prevalence)
Continent point estimate (95% CI) Number of studies I2 point estimate (95% CI) Number of studies I2
North America 0.33 6 33.76% 0.41 5 47.01%
(0.11–0.63) (0.09–0.89)
Europe 0.33 10 23.83% 0.41 8 15.42%
(0.15–0.57) (0.13–0.80)
Asia-Pacific 0.29 10(12 cohorts) 79.31% 0.48 9 79.68%
(0.03–0.74) (0.04–1.24)
MENA 4.24 5 48.71% 4.48 3 28.73%
(2.53–6.31) (1.34–9.00)