Table 5 AE type and outcomes for AEs grade 1–3

BZB

1 enlarged PAVM

1 joint pain

1 facial pain

2 hair loss

1 unresolved/worsened

4 resolved

1 Yes

4 No

1 No

1 No

In 2

1 fatigue

2 hypertension

6 joint pain

1 vertebral fracture

1 confusion

3 headaches

2 proteinuria

1 diarrhea

17 resolved

17 No

In 1

1 fatigue

3 hypertension

1 arterial thrombosis^a

2 joint pain

1 confusion

1 GI bleeding^b

1 diarrhea

1 unresolved/worsened

9 resolved

3 Yes

7 No

2 Yes

1 No

1 Yes

2 No

In 2

TH

5 peripheral neuropathy^c

1 somnolence

1 drowsiness

1 rash

2 unresolved/worsened

6 resolved

3 Yes

5 No

3 Yes

3 No

none

5 peripheral neuropathy^d

4 dizziness

2 somnolence

7 drowsiness

1 constipation

1 erectile dysfunction

7 unresolved/worsened

2 resolved with sequelae

11 resolved

15 Yes

5 No

10 Yes

5 No

15 No

none

1 limb edema

1 arterial thrombosis^f

2 peripheral neuropathy &

2 dizziness

4 unresolved/worsened

2 resolved

4 Yes

2 No

2 Yes

2 No

1 Yes

3 No

In 1