Fig. 1

Mean (± SEM) theta-band power by scalp region and genotype for eyes open and eyes closed conditions. (BLUE = WT, TEAL = HET, YELLOW=HOM). Arrows indicate the direction of significant associations between theta-band power and specific IMPA1 alleles under the recessive FBAT model. Arrows on the left of a graph indicate an association with the wild-type allele within a specific region. Arrows on the right of the graph indicate an association with the mutant allele within a specific region. a In the eyes open condition, significantly lower left frontal theta power was associated with the mutant allele, and significantly greater right frontal theta power was associated with the wild-type allele. The right frontal pattern was also present under the additive FBAT model. b In the eyes closed condition, these differences were not observed. This lateral shift in theta-band power representations on the scalp suggests subtle anatomical or network-level differences may arise during development in the presence of the IMPA1 mutation