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Table 2 First event of diagnosis

From: Comorbidity among HHT patients and their controls in a 20 years follow-up period

 

LPR data

Clinical data

Cases

Controls

P value

Cases

Controls

i value

Total number of patients

73

218

 

73

218

 

Patients with at least one relevant event registered

73

214

 

62

90

 

Potentially HHT-related diagnoses

 Non-traumatic bleedings

44 (60%)

42 (19%)

< 0.001

47 (64%)

16 (7%)

< 0.001

 Bacterial infections

40 (55%)

84 (38%)

0.015

29 (40%)

61 (28%)

0.06

 Thromboembolisms

8 (11%)

38 (17%)

0.19

9 (12%)

29 (13%)

0.83

 Other vascular conditions

14 (19%)

48 (22%)

0.610

5 (7%)

32 (15%)

0.0822

 PAVMs

6 (8%)

0

< 0.001

27 (37%)

0

< 0.001

 Other HHT-related conditions

53 (72%)

0

< 0.001

43 (59%)

0

< 0.001

 Non-HHT-related conditions

70 (95%)

210 (96%)

0.8646

 

Selected Subgroups of diagnoses

 Epistaxis

27 (37%)

4 (2%)

< 0.001

33 (45%)

2 (1%)

< 0.001

 Infections in joints and bones

6 (8%)

1 (0.5%)

< 0.001

5 (7%)

0

< 0.001

  1. The diagnoses were grouped according to clinical relevance for HHT. The time period covers January 1st 1995 to January 1st 2015
  2. The group PAVMs included all patients hospitalised while evaluated for PAVM, in 23 patients PAVM were seen at CT-scan or Pulmonary angiography, while 4 had positive contrast echocardiography, but no PAVM were identified at pulmonary angiography