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Table 2 Specific lymphocyte populations associating with infection frequency in 11 Netherton syndrome patients as analyzed with Spearman’s rank-order correlation

From: Immune cell phenotype and functional defects in Netherton syndrome

Immunological parameter (%) i) Change in NS patients (n = 11) ii) Antibiotic prophylaxis (rs) iii) Antibiotic prophylaxis (p value) Skin infection score iv) (rs) Skin infections (p) Total infection score iv) (rs) Total infection score (p)
Positive correlation
 CD62L expression in CD4 T cells increased 0.764 0.010 0.822 0.007 0.712 0.031
 CD62L expression in CD8 T cells increased 0.745 0.013 0.798 0.006 0.678 0.045
 CD27 expression in CD8 T cells decreased   > 0.05 0.71 0.014   > 0.05
 Naïve CD4 T cells decreased 0.742 0.009 0.798 0.006   > 0.05
 Activated B cells decreased   > 0.05 0.692 0.006 0.613 0.020
Negative correlation
 Memory B cells decreased −0.671 0.009   > 0.05   > 0.05
 Non-switched B cells decreased −0.723 0.004 −0.698 0.006 −0.623 0.017
 CD27 expression in NK cells decreased −0.788 0.004 −0.775 0.005   > 0.05
 Central memory CD8 T cells increased −0.834 0.001 −0.71 0.014   > 0.05
 CD57 expression in CD4 T cells increased −0.822 0.004 −0.798 0.006 −0.678 0.045
 CD57 expression in CD8 T cells increased −0.564 0.070 −0.775 0.005   > 0.05
  1. i) see precise definitions in Additional file 1
  2. ii) compared with age-matched healthy persons
  3. iii) Spearman’s rank correlation coefficient,
  4. iv) Sum of the following scores as specified in Table 1: antibiotics in infancy (0–1), antibiotic prophylaxis (0–2), bacterial skin infections (0–3), conjunctivitis (0–2) and external otitis (0–1)