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Table 2 Comparison of adverse events and serious adverse events between the low-dose and conventional-dose groups

From: Efficacy and safety of low-dose Sirolimus in Lymphangioleiomyomatosis

Type of event Total Low-dose Conventional-dose
Number of patients 39 20 19
Adverse events 35 (89.7) 17 (85.0) 18 (94.7)
 Hypercholesterolaemia 17 (43.6) 7 (35.0) 10 (52.6)
 Stomatitis 14 (35.9) 10 (50.0)* 4 (21.1)
 URI 9 (23.0) 3 (15.0) 6 (31.6)
 Diarrhoea 7 (17.9) 4 (20.0) 3 (15.8)
 Headache 5 (12.8) 4 (20.0) 1 (5.3)
 Vaginal bleeding 5 (12.8) 1 (5.0) 4 (21.1)
 Acneiform lesions 4 (10.3) 3 (15.0) 1 (5.3)
 UTI 4 (10.3) 2 (10.0) 2 (10.5)
Serious adverse events 7 (17.9) 3 (15.0) 4 (21.1)
 Infectiona 4 (10.3) 3 (15.0) 1 (5.3)
 Pneumothorax 3 (7.7) 1 (5.0) 2 (10.5)
 Malignancyb 1 (2.3) 0 (0.0) 1 (5.3)
  1. Data are presented as number (%)
  2. Abbreviations: URI upper respiratory infection, UTI urinary tract infection
  3. *P < .1 (compared with conventional-dose group)
  4. aInfection included pneumonia (n = 3) and cellulitis (n = 1)
  5. bThyroid cancer