Table 2 Comparison of adverse events and serious adverse events between the low-dose and conventional-dose groups
From: Efficacy and safety of low-dose Sirolimus in Lymphangioleiomyomatosis
Type of event | Total | Low-dose | Conventional-dose |
|---|---|---|---|
Number of patients | 39 | 20 | 19 |
Adverse events | 35 (89.7) | 17 (85.0) | 18 (94.7) |
Hypercholesterolaemia | 17 (43.6) | 7 (35.0) | 10 (52.6) |
Stomatitis | 14 (35.9) | 10 (50.0)* | 4 (21.1) |
URI | 9 (23.0) | 3 (15.0) | 6 (31.6) |
Diarrhoea | 7 (17.9) | 4 (20.0) | 3 (15.8) |
Headache | 5 (12.8) | 4 (20.0) | 1 (5.3) |
Vaginal bleeding | 5 (12.8) | 1 (5.0) | 4 (21.1) |
Acneiform lesions | 4 (10.3) | 3 (15.0) | 1 (5.3) |
UTI | 4 (10.3) | 2 (10.0) | 2 (10.5) |
Serious adverse events | 7 (17.9) | 3 (15.0) | 4 (21.1) |
Infectiona | 4 (10.3) | 3 (15.0) | 1 (5.3) |
Pneumothorax | 3 (7.7) | 1 (5.0) | 2 (10.5) |
Malignancyb | 1 (2.3) | 0 (0.0) | 1 (5.3) |