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Table 4 Association between comorbidities and all-cause mortality. Results of Cox proportional hazard model with comorbidities as time-dependent covariate (N = 972)

From: The burden of common variable immunodeficiency disorders: a retrospective analysis of the European Society for Immunodeficiency (ESID) registry data

Comorbidity

HR (95% CI)a

P-Value

HR (95% CI)b

P-Value

Bronchiectasis

0.84 (0.44; 1.62)

0.612

0.83 (0.40; 1.86)

0.633

Splenomegaly

2.11 (1.17; 3.82)

0.013

1.67 (0.82; 3.39)

0.155

Autoimmunity (organ/ systemic)

1.61 (0.79; 3.27)

0.187

1.52 (0.67; 3.43)

0.311

Autoimmune cytopenia

0.72 (0.22; 2.35)

0.591

1.08 (0.33; 3.57)

0.897

Enteropathy

1.39 (0.54; 3.56)

0.493

0.97 (0.28; 3.41)

0.962

Solid tumor

3.19 (1.55; 6.57)

0.002

2.69 (1.10; 6.57)

0.030

Lymphoma

3.95 (1.81; 8.66)

0.001

5.48 (2.36; 12.71)

<.0001

GLILD

3.80 (1.47; 9.85)

0.006

4.85 (1.63; 14.39)

0.005

  1. aunivariable analysis
  2. badjusted for age of CVID symptoms onset