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Table 4 Association between comorbidities and all-cause mortality. Results of Cox proportional hazard model with comorbidities as time-dependent covariate (N = 972)

From: The burden of common variable immunodeficiency disorders: a retrospective analysis of the European Society for Immunodeficiency (ESID) registry data

Comorbidity HR (95% CI)a P-Value HR (95% CI)b P-Value
Bronchiectasis 0.84 (0.44; 1.62) 0.612 0.83 (0.40; 1.86) 0.633
Splenomegaly 2.11 (1.17; 3.82) 0.013 1.67 (0.82; 3.39) 0.155
Autoimmunity (organ/ systemic) 1.61 (0.79; 3.27) 0.187 1.52 (0.67; 3.43) 0.311
Autoimmune cytopenia 0.72 (0.22; 2.35) 0.591 1.08 (0.33; 3.57) 0.897
Enteropathy 1.39 (0.54; 3.56) 0.493 0.97 (0.28; 3.41) 0.962
Solid tumor 3.19 (1.55; 6.57) 0.002 2.69 (1.10; 6.57) 0.030
Lymphoma 3.95 (1.81; 8.66) 0.001 5.48 (2.36; 12.71) <.0001
GLILD 3.80 (1.47; 9.85) 0.006 4.85 (1.63; 14.39) 0.005
  1. aunivariable analysis
  2. badjusted for age of CVID symptoms onset