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Table 1 Baseline characteristics

From: Basal pharmacokinetic parameters of topically applied diacerein in pediatric patients with generalized severe epidermolysis bullosa simplex

Patient number

Age (years)

Sex

Total amount of cream used (g)

Rhein mean daily dose (mg)

Total area treated (cm2)

cmax_urine (ng∙mL−1)

cmax_serum (ng∙mL− 1)

1

8

m

123.4

34

310

39.9

20.1

2

7

m

69.9

19

210

25.0

15.4

  1. Two patients who applied 1% diacerein for a period of four weeks on 3% BSA were included in the pharmacokinetic analysis. Serum and urine samples were taken every two weeks. Detected maximum levels (cmax) of rhein in the urine and serum are given
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172