Table 3 Main characteristics and treatments of PHPT in our series of MEN1 patients
From: Multiple endocrine neoplasia type 1: extensive analysis of a large database of Florentine patients
PHPT | Patients n. (%) | Clinical presentation | Surgery | Pharmacological treatment (Calcimimetic) n. (%) | ||||
|---|---|---|---|---|---|---|---|---|
Symptomatic n. (%) | Asymptomatic n. (%) | No surgery n. (%) | TPT n. (%) | SPT n. (%) | PPT n. (%) | |||
Total patients with PHPT | 139 (95.87%) | 54 (37.24%) | 85 (58.62%) | 40 (28.78%) | 47 (33.81%) - 43 with tissue autograft in the non-dominant forearm - 4 without tissue autograft | 17 (12.23%) | 35 (25.18%) | 26 (18.70%) |
PHPT as first clinical manifestation | 92 (63.45%) | 43 (29.66%) - 29 nephrocalcinosis (20%) - 7 nephrocalcinosis and osteoporosis (4.83%) - 5 osteoporosis (3.45%) - 2 nephrocalcinosis and osteopenia (1.38%) | 49 (33.79%) | 23 (16.55%) | 29 (20.86%) - 28 with tissue autograft in the non-dominant forearm - 1 without tissue autograft | 12 (8.63%) | 28 (20.14%) | 16 (11.51%) |
Index cases (probands) | 85 (58.62%) | 37 (25.52%) - 26 nephrocalcinosis (17.93%) - 5 nephrocalcinosis and osteoporosis (3.45%) - 3 osteoporosis (2.07%) - 2 osteopenia (1.38%) - 1 nephrocalcinosis and osteopenia (0.69%) | 48 (33.10%) | 19 (13.67%) | 33 (23.74%) - 30 with tissue autograft in the non-dominant forearm - 3 without tissue autograft | 10 (7.19%) | 23 (16.55%) | 17 (12.23%) |
Relatives | 54 (37.24%) | 16 (11.03%) - 9 nephrocalcinosis (6.21%) - 4 osteoporosis (2.76%) - 2 nephrocalcinosis and osteoporosis (1.38%) - 1 nephrocalcinosis and osteopenia (0.69%) | 38 (26.21%) | 21 (15.11%) | 14 (10.07%) - 13 with tissue autograft in the non-dominant forearm - 1 without tissue autograft | 7 (5.04%) | 12 (8.63%) | 9 (6.48%) |