Table 1 Baseline characteristics of CHESS sample with severe hemophilia and unmatched cohorts with and without inhibitors
From: Inhibitor clinical burden of disease: a comparative analysis of the CHESS data
Characteristic | All patients | Patients who never developed inhibitors | Patients with current inhibitors | p-valuea |
|---|---|---|---|---|
N = 1149 | N = 1091 | N = 58 | ||
Demographics | ||||
Age, years | ||||
Mean ± SD | 35.50 ± 14.82 | 35.16 ± 14.74 | 41.90 ± 14.95 | .0002 |
Median (range) | 32 (18.00–88.00) | 31 (18.00–88.00) | 39.5 (18.00–80.00) | |
Race, N (%) | ||||
White | 1007 (87.6) | 958 (87.8) | 49 (84.5) | .6260 |
African | 50 (4.4) | 48 (4.4) | 2 (3.4) | |
Asian-Indian subcontinent | 37 (3.2) | 34 (3.1) | 3 (5.2) | |
Asian-Other | 6 (0.5) | 6 (0.5) | 0 (0.0) | |
Middle Eastern | 46 (4.0) | 42 (3.8) | 4 (6.9) | |
Other | 3 (0.3) | 3 (0.3) | 0 (0.0) | |
White | 1007 (87.6) | 958 (87.8) | 49 (84.5) | .4532 |
Non-white | 142 (12.4) | 133 (12.2) | 9 (15.5) | |
Body mass index | ||||
Mean ± SD | 24.76 ± 3.25 | 24.73 ± 3.27 | 25.31 ± 2.78 | .1140 |
Median (range) | 24.57 (14.11–57.47) | 24.51 (14.11–57.47) | 25 (20.52–32.83) | |
Education, N (%) | ||||
None | 15 (1.3) | 12 (1.1) | 3 (5.2) | |
Primary | 51 (4.4) | 49 (4.5) | 2 (3.4) | |
Secondary | 8 (0.7) | 8 (0.7) | 0 (0.0) | |
Undergraduate | 76 (6.6) | 73 (6.7) | 3 (5.2) | |
Graduate | 203 (17.7) | 192 (17.6) | 11 (19.0) | |
Did not answer | 129 (11.2) | 119 (10.9) | 10 (17.2) | |
College or graduate | ||||
Yes | 180 (38.5) | 168 (38.1) | 12 (46.2) | <.0001 |
No | 287 (61.5) | 273 (61.9) | 14 (53.8) | |
Employment status, N (%) | ||||
Full-time employed | 182 (15.8) | 174 (15.9) | 8 (13.8) | |
Homemaker | 1 (0.1) | 1 (0.1) | 0 (0.0) | |
Self-employed | 3 (0.3) | 1 (0.1) | 2 (3.4) | |
Other: Not determined/not specified | 4 (0.4) | 4 (0.4) | 0 (0.0) | |
Part-time employed | 74 (6.4) | 68 (6.2) | 6 (10.3) | |
Retired | 46 (4.0) | 42 (3.8) | 4 (6.9) | |
Student | 84 (7.3) | 82 (7.5) | 2 (3.4) | |
Temporary leave of absence due to my hemophilia | 6 (0.5) | 5 (0.5) | 1 (1.7) | |
Temporary leave of absence due to other reason(s) | 6 (0.5) | 6 (0.5) | 0 (0.0) | |
Unable to work due to my hemophilia | 29 (2.5) | 23 (2.1) | 6 (10.3) | |
Unable to work due to other reason(s) | 2 (0.2) | 2 (0.2) | 0 (0.0) | |
Unemployed, able to work | 40 (3.5) | 40 (3.7) | 0 (0.0) | |
Full-time employed | ||||
Yes | 182 (38.2) | 174 (38.8) | 8 (28.6) | <.0001 |
No | 295 (61.8) | 275 (61.2) | 20 (71.4) | |
Hemophilia type, N (%) | ||||
Hemophilia A | 894 (77.8) | 847 (77.6) | 47 (81.0) | .5438 |
Hemophilia B | 255 (22.2) | 244 (22.4) | 11 (19.0) | |
Comorbidities, N (%) | ||||
None | 586 (51.0) | 578 (53.0) | 8 (13.8) | <.0001 |
Alcohol dependence | 39 (3.4) | 35 (3.2) | 4 (6.9) | .1291 |
Anemia | 65 (5.7) | 57 (5.2) | 8 (13.8) | .0135 |
Anxiety | 162 (14.1) | 150 (13.7) | 12 (20.7) | .1389 |
Depression | 151 (13.1) | 140 (12.8) | 11 (19.0) | .1779 |
Diabetes mellitus | 60 (5.2) | 52 (4.8) | 8 (13.8) | .0084 |
Fibromyalgia | 41 (3.6) | 34 (3.1) | 7 (12.1) | .0034 |
Hepatitis B virus | 20 (1.7) | 19 (1.7) | 1 (1.7) | 1.0000 |
Hepatitis C virus | 61 (5.3) | 56 (5.1) | 5 (8.6) | .2282 |
Human immunodeficiency virus | 31 (2.7) | 28 (2.6) | 3 (5.2) | .2028 |
Hypertension | 139 (12.1) | 126 (11.5) | 13 (22.4) | .0134 |
Hypercholesterolemia | 70 (6.1) | 65 (6.0) | 5 (8.6) | .3931 |
Ischemic heart disease | 19 (1.7) | 16 (1.5) | 3 (5.2) | .0665 |
Obesity | 63 (5.5) | 60 (5.5) | 3 (5.2) | 1.0000 |
Osteoarthritis | 68 (5.9) | 60 (5.5) | 8 (13.8) | .0175 |
Osteoporosis | 11 (1.0) | 11 (1.0) | 0 (0.0) | 1.0000 |
Rheumatoid arthritis | 9 (0.8) | 9 (0.8) | 0 (0.0) | 1.0000 |
Other | 18 (1.6) | 16 (1.5) | 2 (3.4) | .2293 |