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Table 1 Baseline characteristics of CHESS sample with severe hemophilia and unmatched cohorts with and without inhibitors

From: Inhibitor clinical burden of disease: a comparative analysis of the CHESS data

Characteristic All patients Patients who never developed inhibitors Patients with current inhibitors p-valuea
N = 1149 N = 1091 N = 58
Demographics
 Age, years
  Mean ± SD 35.50 ± 14.82 35.16 ± 14.74 41.90 ± 14.95 .0002
  Median (range) 32 (18.00–88.00) 31 (18.00–88.00) 39.5 (18.00–80.00)  
 Race, N (%)
  White 1007 (87.6) 958 (87.8) 49 (84.5) .6260
  African 50 (4.4) 48 (4.4) 2 (3.4)  
  Asian-Indian subcontinent 37 (3.2) 34 (3.1) 3 (5.2)  
  Asian-Other 6 (0.5) 6 (0.5) 0 (0.0)  
  Middle Eastern 46 (4.0) 42 (3.8) 4 (6.9)  
  Other 3 (0.3) 3 (0.3) 0 (0.0)  
  White 1007 (87.6) 958 (87.8) 49 (84.5) .4532
  Non-white 142 (12.4) 133 (12.2) 9 (15.5)  
 Body mass index
  Mean ± SD 24.76 ± 3.25 24.73 ± 3.27 25.31 ± 2.78 .1140
  Median (range) 24.57 (14.11–57.47) 24.51 (14.11–57.47) 25 (20.52–32.83)  
Education, N (%)
 None 15 (1.3) 12 (1.1) 3 (5.2)  
 Primary 51 (4.4) 49 (4.5) 2 (3.4)  
 Secondary 8 (0.7) 8 (0.7) 0 (0.0)  
 Undergraduate 76 (6.6) 73 (6.7) 3 (5.2)  
 Graduate 203 (17.7) 192 (17.6) 11 (19.0)  
 Did not answer 129 (11.2) 119 (10.9) 10 (17.2)  
 College or graduate
  Yes 180 (38.5) 168 (38.1) 12 (46.2) <.0001
  No 287 (61.5) 273 (61.9) 14 (53.8)  
Employment status, N (%)
 Full-time employed 182 (15.8) 174 (15.9) 8 (13.8)  
 Homemaker 1 (0.1) 1 (0.1) 0 (0.0)  
 Self-employed 3 (0.3) 1 (0.1) 2 (3.4)  
 Other: Not determined/not specified 4 (0.4) 4 (0.4) 0 (0.0)  
 Part-time employed 74 (6.4) 68 (6.2) 6 (10.3)  
 Retired 46 (4.0) 42 (3.8) 4 (6.9)  
 Student 84 (7.3) 82 (7.5) 2 (3.4)  
 Temporary leave of absence due to my hemophilia 6 (0.5) 5 (0.5) 1 (1.7)  
 Temporary leave of absence due to other reason(s) 6 (0.5) 6 (0.5) 0 (0.0)  
 Unable to work due to my hemophilia 29 (2.5) 23 (2.1) 6 (10.3)  
 Unable to work due to other reason(s) 2 (0.2) 2 (0.2) 0 (0.0)  
 Unemployed, able to work 40 (3.5) 40 (3.7) 0 (0.0)  
 Full-time employed
  Yes 182 (38.2) 174 (38.8) 8 (28.6) <.0001
  No 295 (61.8) 275 (61.2) 20 (71.4)  
Hemophilia type, N (%)
 Hemophilia A 894 (77.8) 847 (77.6) 47 (81.0) .5438
 Hemophilia B 255 (22.2) 244 (22.4) 11 (19.0)  
Comorbidities, N (%)
 None 586 (51.0) 578 (53.0) 8 (13.8) <.0001
 Alcohol dependence 39 (3.4) 35 (3.2) 4 (6.9) .1291
 Anemia 65 (5.7) 57 (5.2) 8 (13.8) .0135
 Anxiety 162 (14.1) 150 (13.7) 12 (20.7) .1389
 Depression 151 (13.1) 140 (12.8) 11 (19.0) .1779
 Diabetes mellitus 60 (5.2) 52 (4.8) 8 (13.8) .0084
 Fibromyalgia 41 (3.6) 34 (3.1) 7 (12.1) .0034
 Hepatitis B virus 20 (1.7) 19 (1.7) 1 (1.7) 1.0000
 Hepatitis C virus 61 (5.3) 56 (5.1) 5 (8.6) .2282
 Human immunodeficiency virus 31 (2.7) 28 (2.6) 3 (5.2) .2028
 Hypertension 139 (12.1) 126 (11.5) 13 (22.4) .0134
 Hypercholesterolemia 70 (6.1) 65 (6.0) 5 (8.6) .3931
 Ischemic heart disease 19 (1.7) 16 (1.5) 3 (5.2) .0665
 Obesity 63 (5.5) 60 (5.5) 3 (5.2) 1.0000
 Osteoarthritis 68 (5.9) 60 (5.5) 8 (13.8) .0175
 Osteoporosis 11 (1.0) 11 (1.0) 0 (0.0) 1.0000
 Rheumatoid arthritis 9 (0.8) 9 (0.8) 0 (0.0) 1.0000
 Other 18 (1.6) 16 (1.5) 2 (3.4) .2293
  1. Abbreviations: CHESS, Cost of Haemophilia across Europe – a Socioeconomic Survey; SD, standard deviation
  2. aP-values were derived from a paired t-test or Wilcoxon signed rank test for continuous post-match variables and the McNemar’s test or exact McNemar’s test for categorical variables; p < .05 indicates statistical significance