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Table 4 Results of the Disbenefit Analysis

From: Economic impact of screening for X-linked Adrenoleukodystrophy within a newborn blood spot screening programme

  Male babies only screened Both sexes screened
Undiscounted Discounted Undiscounted Discounted
Non CCALD X-ALD 8.61 8.61 8.61 8.61
Age of symptomatic presentation 35.00 20.55 35.00 20.55
Person years without diagnosis 301.34 176.95 301.34 176.95
Non X-ALD disorders 6.68 6.68 13.04 13.04
Age of symptomatic presentation 5.00 4.66 5.00 4.66
Person years without diagnosis 33.39 31.11 65.21 60.76
Number of cases of X-ALD in females 17.36 17.36
Age of symptomatic presentation 50.00 24.11
Person years without diagnosis 867.96 418.60
Total person years without diagnosis 334.73 208.06 1234.52 656.32
Total incremental QALYs from screening 280.15 82.42 279.78 82.30
Maximum QALY decrement per non CCALD case per year 0.84 0.40 0.23 0.13
  1. – No cases in females when only male babies are screened