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Table 4 Results of the Disbenefit Analysis

From: Economic impact of screening for X-linked Adrenoleukodystrophy within a newborn blood spot screening programme

 

Male babies only screened

Both sexes screened

Undiscounted

Discounted

Undiscounted

Discounted

Non CCALD X-ALD

8.61

8.61

8.61

8.61

Age of symptomatic presentation

35.00

20.55

35.00

20.55

Person years without diagnosis

301.34

176.95

301.34

176.95

Non X-ALD disorders

6.68

6.68

13.04

13.04

Age of symptomatic presentation

5.00

4.66

5.00

4.66

Person years without diagnosis

33.39

31.11

65.21

60.76

Number of cases of X-ALD in females

–

–

17.36

17.36

Age of symptomatic presentation

–

–

50.00

24.11

Person years without diagnosis

–

–

867.96

418.60

Total person years without diagnosis

334.73

208.06

1234.52

656.32

Total incremental QALYs from screening

280.15

82.42

279.78

82.30

Maximum QALY decrement per non CCALD case per year

0.84

0.40

0.23

0.13

  1. – No cases in females when only male babies are screened