Sensitivity analyses | Screening | No screening | Incremental | ||||||
---|---|---|---|---|---|---|---|---|---|
Total Costs (m) | Total QALYs | Total Costs (m) | Total QALYs | Costs (m) | 95% Confidence Interval (m) | QALYs | 95% Confidence Interval | ICER | |
Base case | £3.01 | 390 | £6.44 | 307 | -£3.04 | (−£5.69, −£1.19) | 82 | (43, 139) | Dominates |
Incidence rate doubled | £5.97 | 778 | £12.88 | 614 | -£6.50 | (−£11.74, −£2.80) | 164 | (86, 277) | Dominates |
Incidence rate halved | £1.51 | 194 | £3.21 | 153 | -£1.30 | (−£2.62, −£0.39) | 41 | (22, 69) | Dominates |
CCALD 10% of total X-ALD | £2.02 | 412 | £2.21 | 397 | £0.21 | (−£0.06, £0.46) | 16 | (9, 24) | £13,600 |
CCALD 15% of total X-ALD | £2.13 | 409 | £2.70 | 386 | -£0.17 | (−£0.63, £0.22) | 23 | (14, 36) | Dominates |
CCALD 60% HSCT rate | £5.20 | 340 | £6.41 | 307 | -£0.81 | (−£2.01, £0.02) | 33 | (15, 60) | Dominates |
CCALD 10% of total X-ALD and 80% HSCT rate | £2.23 | 407 | £2.21 | 396 | £0.42 | (£0.24, £0.62) | 11 | (6, 17) | £38,701 |
CCALD 15% of total X-ALD and 80% HSCT rate | £2.43 | 401 | £2.69 | 385 | £0.15 | (−£0.18, £0.42) | 16 | (9, 26) | £8927 |
CCALD 20% of total X-ALD and 80% HSCT rate | £2.65 | 396 | £3.18 | 375 | -£0.12 | (−£0.59, £0.24) | 22 | (13, 34) | Dominates |
1.5% Discount Rate | £4.59 | 611 | £9.35 | 455 | -£4.36 | (−£7.97, −£1.81) | 156 | (83, 260) | Dominates |
Both girls and boys screened | £3.27 | 800 | £6.96 | 718 | -£3.27 | (−£5.97, −£1.36) | 82 | (43, 139) | Dominates |