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Table 1 Main project topics and outputs

From: Recent advances in methodology for clinical trials in small populations: the InSPiRe project

Efficient study design  
Optimal designs for confirmatory studies using decision-theoretic and value-of-information (VOI) approaches Design of confirmatory studies with stratified populations for personalized medicines
Key publications: [1215] Key publications: [17, 2023]
Improved analysis and evidence synthesis
Incorporation of pharmacokinetics (PK) and pharmacodynamics (PD) data in early-phase dose-finding studies Meta-analysis methods for small trials or small numbers of trials
Key publications: [25, 2730] Key publications: [33, 34, 3638, 40, 41]
Open-source R software: dfpk [26], dfped [29] Open-source R software: bayesmeta [35], nmaINLA [42]