Table 1 Main project topics and outputs

Efficient study design

Optimal designs for confirmatory studies using decision-theoretic and value-of-information (VOI) approaches

Design of confirmatory studies with stratified populations for personalized medicines

Key publications: [12–15]

Key publications: [17, 20–23]

Improved analysis and evidence synthesis

Incorporation of pharmacokinetics (PK) and pharmacodynamics (PD) data in early-phase dose-finding studies

Meta-analysis methods for small trials or small numbers of trials

Key publications: [25, 27–30]

Key publications: [33, 34, 36–38, 40, 41]

Open-source R software: dfpk [26], dfped [29]

Open-source R software: bayesmeta [35], nmaINLA [42]