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Table 2 RANK/RANKL/OPG triad and NFATc1 expression by cherubism-granuloma cells

From: Molecular and cellular characterizations of human cherubism: disease aggressiveness depends on osteoclast differentiation

 

RANK

RANK-L

OPG

NFAT-c1

Stromal cells (cytoplasmic)

CMGC (cytoplasmic)

Stromal cells

MGC

Stromal cells

MGC

cMGC (cytoplasmic)

cMGC (Nuclear)

1-A

1-B1

+

+

+

1-B2

+

1-C1

+

+

+

+

+

+

1-C2

+

+

+

+

+

+

2-A

NA

+

2-B

+

+

+

  1. Expression of each protein was evaluated for MGC and stromal cells. For NFATc1, numbers of nuclear and cytoplasmic positive cells were evaluated. For each assay five randomly selected areas were evaluated (200× high-power field)