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Table 1 Patient classification

From: Molecular and cellular characterizations of human cherubism: disease aggressiveness depends on osteoclast differentiation

Age

Classification

Definition

Patient

Age at surgery (years)

Gender

Radiological grade

SH3BP2 mutation

Evolution

Child Patients

1-A

Low degree of aggressiveness: radiologic grade I with a favorable evolution after surgery

1-A

16

M

I.2

c.1244 G > A

Favorable

1-B

Moderate degree of aggressiveness: radiologic grade II-IV with a favorable evolution after surgery

1-B1

9

F

II.1

c.1244 G > A

Favorable

1-B2

8

M

II.1

c.1244 G > A

Favorable

1-C

High degree of aggressiveness: radiologic grade I-VI with an unfavorable evolution after surgery

1-C1

8

M

V

c.1244 G > A

Unfavorable (recurrence and extension)

1-C2

7

M

VI

c.1253 C > G

Unfavorable (recurrence and extension)

Adult Patients

2-A

Remodeling bone

2-A

19

F

N/A

c.1244 G > A

N/A

2-B

Acute exacerbation

2-B

45

F

VI.3

c.1244 G > A

N/A

  1. Cherubism cases were classified according to their age at surgery and sub-classified according to granuloma aggressiveness based on radiologic classification [20] and evolution after surgery. Age at the surgery, gender, radiologic grade, evolution and type of SH3BP2 mutation are shown