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Fig. 6 | Orphanet Journal of Rare Diseases

Fig. 6

From: Molecular and cellular characterizations of human cherubism: disease aggressiveness depends on osteoclast differentiation

Fig. 6

Cytokine expression in culture supernatant. The supernatant of both cell-culture types (standard medium and osteoclastogenic medium) was studied at day 3 and day 7. TNF-α was detected in the supernatant of all cultures. IL-6 was detected in the supernatant of all cultures at a higher level than TNF-α. OPG was detected in the supernatant of all cultures, whereas RANK-L levels were lower than OPG. D3 and D7 (3rd and 7th days of culture in standard medium), D3+ and D7+ (3rd and 7th days of culture in osteoclastogenic medium). RANK-L (receptor of activated nuclear factor kappa B ligand), OPG (osteoprotegerin), M-CSF (macrophage colony stimulating factor), IL (interleukin), TNF (tumor necrosis factor)

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172