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Fig. 4 | Orphanet Journal of Rare Diseases

Fig. 4

From: Molecular and cellular characterizations of human cherubism: disease aggressiveness depends on osteoclast differentiation

Fig. 4

Cherubism giant multinucleated cells differentiate into osteoclasts in culture. Cultures in standard and osteoclastogenic media of cherubism granuloma at day 7 (cases 1B-1, 1B-2, 1-C1, 1-C2, 2-B) compared to osteoclasts obtained from healthy-donor PBMC-differentiation cultures at day 14 (control). 1-A: Cherubism differentiates into osteoclast (> 3 nuclei, TRAP+ cells) at day 7 in standard and osteoclastogenic media. Number of osteoclasts at day 7 in cherubism is not significantly different from the PBMC culture at day 14. 1-B: Number of nuclei of cherubism osteoclasts at day 7 cultivated in osteoclastogenic medium is significantly increased compared to the number of nuclei in osteoclasts from PBMC culture at day 14 (p = 0.002). 1-C: Size of cherubism osteoclasts at day 7 cultivated in osteoclastogenic or standard medium is not significantly different from the size of healthy donor osteoclasts

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172