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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Molecular and cellular characterizations of human cherubism: disease aggressiveness depends on osteoclast differentiation

Fig. 2

Characterization of cells present in cherubism granulomas (CD5, CD8, CD68, TRAP activity). (CD5, CD8, CD68 scale bar = 100 μm; TRAP activity scale bar = 50 μm). a-d: Case 1-B1, child with moderately aggressive cherubism: granuloma is composed of fibroblastic stroma with CD8+ cells and monocytes. a Identification of lymphoid cells (black arrow: CD5-positive cells) within the stroma. b Identification CD8+ lymphoid cells (black arrow: CD8-positive cells) within the stroma. c Identification CD68-positive cells, principally composed of monocytes (black arrow: mononuclear CD68-positive cell); and few macrophages (red arrow: multinuclear CD68-positive cell). d TRAP assay (× 20) showed that MGC are TRAP negative (considered as macrophages: red arrow). e-h Case 1-C1, child with highly aggressive cherubism. Granuloma is composed of fibroblastic stroma with CD8+ cells and osteoclast-like cells. e CD5 staining showed lymphoid cells within the stroma (black arrow). f CD8 staining showed CD8+ lymphoid cells within the stroma (black arrow). g CD68 staining showed cells principally composed of macrophages (multinuclear CD68-positive cell, red arrow) and monocytes (mononuclear CD68-positive cell, black arrow). h TRAP assay showed numerous TRAP-positive MGC (osteoclasts, red arrow). TRAP: Tartrate Resistant Acid Phosphatase

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