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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: Molecular and cellular characterizations of human cherubism: disease aggressiveness depends on osteoclast differentiation

Fig. 1

Histopathological characteristics of cherubism granulomas. Granuloma sections were stained with HES (hematoxylin-eosin-safranin). Cherubism granulomas are heterogeneous lesions both within a granuloma and among patients (scale bar 200 μm). a Case 1-C1 showed multinucleated giant cells (black arrows) (MGC), mononuclear cells and collagen (safaranin-orange coloration) stroma. b Case 1-C1 showed fibrous collagen-rich stroma, vessels (black arrow) with hyalinosis cuffing. c Case 1-B1 showed MGC (black arrows), with mononuclear cells and a collagen (safranin)-rich stroma. d Case 1-B1 showed a fibrous collagen-rich stroma. e Case 2-A showed immature bone within a fibrous stroma. f Case 2-B showed MGC with intracytoplasmic vacuoles (black arrows), mononuclear cells and collagen (safaranin-orange coloration) stroma

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