From: TSC-associated neuropsychiatric disorders (TAND): findings from the TOSCA natural history study
TAND Features | Individuals With Manifestation, n (%)a | Individuals With Available Data, n (%) | Individuals with Data Not Available*, n (%) |
---|---|---|---|
Behavioural level | |||
Overactivity | 337 (45.0) | 749 (33.8) | 1467 (66.2) |
Sleep difficulties | 331 (43.9) | 754 (34.0) | 1462 (66.0) |
Impulsivity | 317 (42.7) | 742 (33.5) | 1474 (66.5) |
Anxiety | 240 (33.3) | 720 (32.5) | 1496 (67.5) |
Mood swings | 214 (29.8) | 718 (32.4) | 1498 (67.6) |
Severe aggression | 183 (24.3) | 754 (34.0) | 1462 (66.0) |
Depression mood | 139 (19.2) | 724 (32.7) | 1492 (67.3) |
Self-injury | 117 (15.5) | 755 (34.1) | 1461 (65.9) |
Obsessions | 100 (14.0) | 714 (32.2) | 1502 (67.8) |
Psychosis | 40 (5.5) | 725 (32.7) | 1491 (67.3) |
Hallucinations | 26 (3.6) | 719 (32.5) | 1497 (67.5) |
Psychiatric level | |||
ASD | 314 (21.1) | 1486 (67.1) | 730 (32.9) |
ADHD | 268 (19.1) | 1404 (63.4) | 812 (36.6) |
Anxiety disorder | 133 (9.7) | 1365 (61.6) | 851 (38.4) |
Depressive disorder | 84 (6.1) | 1371 (61.9) | 845 (38.1) |
Intellectual level | |||
Normal | 393 (44.4) | 885 (39.9) | 1331 (60.1) |
Mild ID | 249 (28.1) | 885 (39.9) | 1331 (60.1) |
Moderate ID | 134 (15.1) | 885 (39.9) | 1331 (60.1) |
Severe ID | 82 (9.3) | 885 (39.9) | 1331 (60.1) |
Profound ID | 27 (3.1) | 885 (39.9) | 1331 (60.1) |
Academic level | |||
Individuals ever had difficulties in academic performance | 735 (58.6) | 1254 (56.6) | 962 (43.4) |
Individuals assessed for academic difficulties | 359 (48.8)b | NA | NA |
Neuropsychological level | |||
Individuals ever had any neuropsychological skill assessed | 564 (41.6) | 1355 (61.1) | 861 (38.9) |
Individuals with performance <5th percentile | 314 (55.7)c | NA | NA |